Active Recombinant Human Il1A, HIgG1 Fc-tagged, mutant
|Product Overview :||The extracellular domain of human IL-1a (NP_000566.3)(Ser113-Ala271) is fused to the N-terminus of the Fc region of mutant human IgG1was expressed in CHO cell.|
- Gene Information
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|Description :||The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropiccytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine isproduced by monocytes and macrophages as a proprotein, which is proteolytically processed and released inresponse to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form acytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associatedwith rheumatoid arthritis and Alzheimer"s disease.|
|Source :||CHO cell|
|Tag :||HIgG1 Fc-tagged, mutant|
|Form :||Lyophilized from 0.2μm-filtered solution in PBS.|
|Bio-activity :||cytokine activity; interleukin-1 receptor binding; protein binding|
|Molecular Mass :||44KDa (monomer)|
|AA Sequence :||Ser113-Ala271|
|Endotoxin :||<0.06 eu/μg as determined by lal>0.06>|
|Purity :||>98%, by SDS-PAGE under reducing conditions.|
|Stability :||Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.|
|Reconstitution :||Reconstitute at 100μg/ml in sterile PBS.|
|Warning :||Avoid freeze/thaw cycles.|
|Gene Name :||IL1A interleukin 1, alpha [ Homo sapiens ]|
|Official Symbol :||IL1A|
|Synonyms :||IL1A; interleukin 1, alpha; IL1; interleukin-1 alpha; hematopoietin 1; IL 1A; IL1 ALPHA; IL1F1; preinterleukin 1 alpha; pro interleukin 1 alpha; IL-1 alpha; hematopoietin-1; pro-interleukin-1-alpha; IL-1A; IL1-ALPHA;|
|Gene ID :||3552|
|mRNA Refseq :||NM_000575|
|Protein Refseq :||NP_000566|
|UniProt ID :||P01583|
|Chromosome Location :||2q14|
|Pathway :||Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Cytokines and Inflammatory Response, organism-specific biosystem; FAS pathway and Stress induction of HSP regulation, organism-specific biosystem;|
|Function :||copper ion binding; cytokine activity; interleukin-1 receptor binding; protein binding;|
|IL1A-2911HCL||Recombinant Human IL1A cell lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (10)Ask a question
Cross-talk between IL-1α's and other cytokines is dissected through methods such as co-immunoprecipitation, ELISA, and cytokine profiling arrays.
IL-1α's paradoxical roles are dissected using conditional knockout mice, 3D culture systems, and molecular analyses to delineate context-specific effects.
Single-cell RNA sequencing uncovers heterogeneity in IL-1α-responsive cell populations and their roles, revealing distinct molecular profiles and functions.
IL-1α's intricate pro-inflammatory signaling pathways are decoded using advanced techniques like mass spectrometry, phosphoproteomics, and bioinformatics.
Genetic editing tools like CRISPR-Cas9 unveil IL-1α's contributions to diseases by generating knockout models and studying resulting phenotypic changes.
In vitro co-culture systems are manipulated to study IL-1α-mediated responses, elucidating immune-stromal cell interactions via cytokine-specific neutralization.
Specific cellular receptors and effectors influenced by IL-1α are identified through techniques like co-immunoprecipitation, ChIP-seq, and siRNA knockdown.
Live-cell microscopy captures real-time IL-1α release dynamics and its impact on neighboring cells, facilitated by fluorescent tagging and high-resolution imaging.
Longitudinal studies and statistical modeling establish the quantitative relationship between IL-1α levels and disease progression, offering predictive insights.
Multi-omics analyses provide a holistic view of IL-1α signaling's impact, integrating transcriptomics, proteomics, and metabolomics data for comprehensive insights.
Customer Reviews (3)Write a review
High solubility. -
Good for intracellular staining. -
Effective in apoptosis assays. -
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