| Description : |
Interleukin-4 Receptor, also known as IL-4RA and CD124, is a transmembrane glycoprotein belonging to the class I receptor family. It is highly expressed by activated T-cells. IL-4RA couples with γ chain to form the type I receptor for IL-4. The extracellular domain of IL-4RA binds to IL-4 and antagonizes its activity. IL-4RA plays an important role in Th2 cell differentiation, Ig class switching and alternative macrophage activation. It has also been implicated in allergic inflammation, tumor progression and atherogenesis. |
| Source : |
HEK 293 |
| Species : |
Human |
| Form : |
Sterile Filtered White lyophilized (freeze-dried) powder. |
| Bio-activity : |
ED50 < 70 ng/mL, measured in a neutralization assay using TF-1 cells in the presence of 0.5 ng/mL h-IL-4. |
| Molecular Mass : |
40-45 kDa, observed by reducing SDS-PAGE. |
| AA Sequence : |
GNMKVLQEPTCVSDYMSISTCEWKM NGPTNCSTELRLLYQLVFLLSEAHT CIPENNGGAGCVCHLLMDDVVSADN YTLDLWAGQQLLWKGSFKPSEHVKP RAPGNLTVHTNVSDTLLLTWSNPYP PDNYLYNHLTYAVNIWSENDPADFR IYNVTYLEPSLRIAASTLKSGISYR ARVRAWAQCYNTTWSEWSPSTKWHN SYREPFEQH |
| Endotoxin : |
< 0.2 EU/μg, determined by LAL method. |
| Purity : |
> 95% as analyzed by SDS-PAGE and HPLC. |
| Storage : |
Lyophilized recombinant Human Interleukin-4 Receptor remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, Human Interleukin-4 Receptor should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade. |
| Storage Buffer : |
Lyophilized after extensive dialysis against PBS. |
| Reconstitution : |
Reconstituted in ddH2O or PBS at 100 μg/mL. |
