Active Recombinant Human Thrombopoietin

• Cat.No.: THPO-27H
• Product Overview: Recombinant Human THPO (Ser22-Gly349) was produced in HEK293 Cells.

Specification

• Species: Human
• Source: HEK293
• Tag: Non
• Protein Length: 22-349 a.a.
• Description: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.
• Molecular Mass: 37.4 kDa
• Formulation: Lyophilized from 0.22 μm filtered solution in 50mM Tris 150mM NaCl pH 7.0. Normally Mannitol or Trehalose are added as protectants before lyophilization.
• Purity: >95% as determined by SDS-PAGE.
• Endotoxin: Less than 1.0 EU per μg of the rhTPO by the LAL method.
• Bioactivity: The bio-activity was determined by dose-dependent stimulation of the proliferation of MO7e cells. The ED50<1ng/ml, corresponding to a specific activity of >1X106 Unit/mg.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4oC-8oC); After reconstitution under sterile conditions for 1 month (4oC-8oC) or 3 months (-20oC to -70oC).
• OfficialSymbol: THPO

Gene Information

• Gene Name: THPO thrombopoietin [ Homo sapiens ]
• Synonyms: THPO; thrombopoietin; ML; TPO; MGDF; MKCSF; MPLLG; MGC163194; MPL ligand; c-mpl ligand; thrombopoietin nirs variant 1; megakaryocyte stimulating factor; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand
• Gene ID: 7066
• mRNA Refseq: NM_000460
• Protein Refseq: NP_000451
• MIM: 600044
• UniProt ID: P40225
• Chromosome Location: 3q27
• Pathway: Hematopoietic cell lineage; Platelet Aggregation (Plug Formation); Platelet activation, signaling and aggregation
• Function: cytokine activity; growth factor activity; hormone activity