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Active Recombinant Mouse Il3

Cat.No. : Il3-644M
Product Overview : Recombinant Mouse Il3 (Accession # NP_034686) Asp33-Cys166, fused with an N-terminal Met, was produced in E. coli.
Availability February 15, 2025
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Source : E. coli
Species : Mouse
Predicted N Terminal : Asp33
Form : Lyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein.
Bio-activity : Measured in a cell proliferation assay using NFS-60 mouse myelogenous leukemia lymphoblast cells. Holmes, K.L. et al. (1985) Proc. Natl. Acad. Sci. USA 82:6687.The ED50 for this effect is typically 20-100 pg/mL.
Molecular Mass : Recombinant Mouse Il3, Met-tagged has a calculated MW of 15 kDa.
Protein length : Asp33-Cys166
Purity : >97%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Storage : Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
Reconstitution : Reconstitute at 10 µg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Gene Name : Il3 interleukin 3 [ Mus musculus ]
Official Symbol : Il3
Synonyms : IL3; interleukin 3; interleukin-3; mast cell growth factor; P-cell-stimulating factor; hematopoietic growth factor; multipotential colony-stimulating factor; BPA; PSF; HCGF; Il-3; MCGF; Csfmu;
Gene ID : 16187
mRNA Refseq : NM_010556
Protein Refseq : NP_034686
MIM :

Not For Human Consumption!

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Customer Reviews (3)

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06/20/2022

    I've used many brands, but this one is one of my favorites.

    03/08/2021

      The performance is very stable and the price is very reasonable. I would definitely buy this product again.

      12/19/2020

        I have recommended this brand to my colleagues and friends, and they all praise this product.

        Q&As (16)

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        What is the difference between IL-3 and GM-CSF In vitro? 04/14/2023

        In vitro, IL-3 can induce differentiation and proliferation of myeloid lineage cells and is distinguished from GM-CSF by the relative increase in production of platelets, basophils, and mast cells.

        What is the difference in clinical presentation of IL-3 compared to GM-CSF? 04/14/2023

        Although effective, IL-3 appears to present no therapeutic advantages compared to G-CSF and GM-CSF, and in direct comparison studies, IL-3 led to a considerably higher rate of adverse events than either of the other cytokines.

        Since the structure of IL-3 is different between animals and humans, does it mean that il-3 is not necessary to maintain stable hematopoietic function? 04/14/2023

        mice deficient in both bc and IL-3 show the same phenotype as the bc-deficient mice, conclusively demonstrating that, for the most part, the GM-CSF/IL3/IL5 family is not essential for steady-state production of myeloid cells

        How does the structure of IL-3 in animals differ from that in humans? 04/14/2023

        Unlike in humans, murine IL-3 has a second b chain receptor, bcIL3, which bears 91% homology to the bc chain.

        Does loss of cytokine IL-3 affect normal granulocyte, monocyte, and basophil levels? 04/14/2023

        Knockout mice were also reported with surprisingly limited phenotypes. Despite the ability of the three cytokines to stimulate hematopoiesis, mice functionally deficient in all three cytokinesdisplay normal circulating levels of granulocytes, monocytes, and basophils.

        IL-3 specific receptor subunit CD123 is overexpressed in many hematological malignancies,Is it overexpressed in normal tissues where inflammation occurs? 04/14/2023

        non-hematopoietic (e.g., epithelial cells, and fibroblasts) cell subsets can also produce il-3.

        When is IL-3 activated by T cells? 04/14/2023

        Such as allergic inflammation and parasitic infestation.

        Since basophils are the target and source of IL-3, can they regulate the secretion of IL-3 to treat allergic diseases? 04/14/2023

        IL-3 can regulate the survival of basophil granulocytes and cytokine production through autocrine, so as to achieve the purpose of treating allergic diseases.

        T cell IL-3 expression is specifically regulated by which transcription factor? 04/14/2023

        Bhlhe40

        Which hematopoietic and non-hematopoietic cell subsets express IL-3? 04/14/2023

        E.g., lymphocytes,epithelial cells, and fibroblasts

        Are there any completed clinical trials on IL3? 12/20/2021

        Yes, there are some completed clinical trials on IL3 results, but the specific results need to refer to the relevant research papers.

        What is the effect of IL3 on hematopoietic system? 09/29/2021

        This protein can promote stem cell proliferation and differentiation during hematopoietic process, thus increasing the production of different types of blood cells.

        Are there any side effects of IL3? 09/24/2019

        In general, the IL3 has relatively few side effects, but some unpleasant symptoms such as fever, headache and nausea may occur.

        IL3 associated with whether the immune adjustment? 06/28/2019

        IL3 can regulate the body's immune response and the function of immune cells, and plays an important role in immune regulation.

        What is the solubility and stability of IL3? 05/25/2019

        IL3 generally have good solubility and stability, making them easier to handle during drug preparation and storage.

        How is the research progress of IL3? 02/27/2019

        The study of IL3 is ongoing, including its application in the development of therapeutic drugs, as well as in combination therapy with other immune molecules.

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