Active Recombinant Mouse Il3ra Protein, Fc-tagged, Alexa Fluor 488 conjugated
|Product Overview :||Alexa Fluor 488 conjugated recombinant mouse Il3ra protein was expressed in Spodopterafrugiperdawith the Fc part of Human IgG1 Pro100-Lys330 (C-terminus) and MouseIl3ra Ser17-Lys331 (N-terminus).|
- Gene Information
- Related Products
|Description :||Il3ra isa pleiotropic cytokine produced primarily by activated T cells or mast cells.Il3ra stimulates the proliferation and differentiation of hemopoietic cellsincluding the pluripotent hematopoietic stem cells as well as various lineage-committedcells. The biological effects of Il3ra on the various cell types are mediatedby the binding of Il3ra to specific cell surface receptor complexes. Thefunctional high-affinity IL-3 receptor is a heterodimer consisting of aligand binding α subunit and the β subunit. The α subunit alone binds Il3rawith low affinity.|
|Source :||Insect cells|
|Bio-activity :||Measuredby its ability to inhibit the IL-3-induced proliferation of NFS-60 mouse myeloidcells. The ED50 for this effect is typically 0.03-0.15 μg/mL in the presenceof 2.5 μg/mL Recombinant Mouse IL-3 Rβ Fc Chimera and 2 ng/mL of RecombinantMouse Il3ra.|
|Molecular Mass :||61.0 kDa (monomer); SDS-PAGE: 70-80kDa, reducing conditions.|
|N-terminal Sequence Analysis :||Ser 17|
|Endotoxin :||< 1.0 EU/ μg of the protein by the LAL method.|
|Purity :||> 90 % by SDS-PAGE and analyzed by silver stain|
|Characteristic :||Disulfide-linked homodimer
Labeled with Alexa Fluor 488 via amines
Excitation Wavelength: 488 nm
Emission Wavelength: 515-545 nm
|Storage :||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 centigrade as supplied.
1 month, 2 centigrade under sterile conditions after reconstitution.
3 months, -20 to -70 centigrade under sterile conditions after reconstitution.
|Concentration :||100 μg/mL|
|Storage Buffer :||Lyophilizedfrom a 0.2 μm filtered solution in PBS.|
|Reconstitution :||100 μg/mL in sterile PBS|
|Gene Name :||Il3ra interleukin 3 receptor,alpha chain [ Mus musculus ]|
|Official Symbol :||Il3ra|
|Synonyms :||Il3ra; interleukin 3receptor, alpha chain; CD123; SUT-1; CDw123; interleukin-3 receptor subunit alpha; IL-3RA; IL-3R-alpha; Il-3 alpha subunit; IL-3R subunit alpha; IL-3 receptor alpha chain; IL-3 receptor subunit alpha; IL-3 receptor alpha SP2 isoform; interleukin-3 receptor class II alpha chain|
|Gene ID :||16188|
|mRNA Refseq :||NM_008369|
|Protein Refseq :||NP_032395|
|UniProt ID :||P26952|
|◆ Recombinant Protein|
|IL3RA-5184H||Active Recombinant Human IL3RA Protein, His/Flag/StrepII-tagged||+Inquiry|
|IL3RA-1176H||Recombinant Human IL3RA Protein, His (Fc)-Avi-tagged||+Inquiry|
|IL3RA-1120H||Recombinant Human IL3RA Protein (Met1-Arg305), HlgG1 Fc-tagged||+Inquiry|
|IL3RA-4517M||Recombinant Mouse IL3RA Protein, His (Fc)-Avi-tagged||+Inquiry|
|IL3RA-06H||Recombinant Human IL3RA Protein, C-Fc-Avi tagged, Biotinylated||+Inquiry|
|IL3RA-2433HCL||Recombinant Human IL3RA cell lysate||+Inquiry|
|IL3RA-742CCL||Recombinant Canine IL3RA cell lysate||+Inquiry|
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The feasibility of personalized therapy depends on the specific disease type and patient situation, and more research is needed to determine the application of personalized therapy to Il3ra.
Il3ra has certain promise in clinical application, especially in the treatment of immune-related diseases.
Regulates the proliferation and differentiation of immune cells by binding to its interacting cytokine IL-3, and plays a role in regulating the function of the immune system.
Clinical trials of recombinant Il3ra have been conducted in different disease areas. At present, some early trials show its potential in the treatment of certain diseases, but more research is needed to verify its efficacy and safety.
The Il3ra can regulate the proliferation and differentiation of different types of immune cells in the immune system, thus affecting the function of the immune system.
Il3ra is generally well tolerated, but some minor side effects such as headache and nausea may occur. Serious side effects are rare.
Customer Reviews (3)Write a review
It is highly specific, that is, it binds only to its receptor IL-3R, and it has high potential in fighting disease and drug discovery -
Depending on the need, different IL-3Rα variants or mutants can be customized through techniques such as genetic modification to achieve the production of their specific properties. -
IL-3rα, by binding to its receptor, plays an important role in regulating biological processes such as cell proliferation and differentiation, and its biological activity needs to be guaranteed and can be detected by biological identification and other methods. -
Ask a Question for All Il3ra Products
Required fields are marked with *
My Review for All Il3ra Products
Required fields are marked with *