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Active Recombinant Rat Il18 Protein (159 aa)

Cat.No. : Il18-368I
Product Overview : Recombinant rat Interleukin-18 (rrIL-18) produced in E. coli is a single non-glycosylated polypeptide chain containing 159 amino acids. A fully biologically active molecule, rrIL-18 has a molecular mass of 18.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques.
  • Specification
  • Gene Information
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Description : Interleukin-18 (IL18, also known as interferon-gamma inducing factor or IGIF) is a cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. Its biological activity is pleiotropic and it has been shown to induce interferon-gamma production in KG-1 cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production in B cells.
Source : E. coli
Species : Rat
Form : Sterile Filtered White lyophilized (freeze-dried) powder.
Bio-activity : ED50 < 2 μg/mL resulted in the secretion of 0.15 ng/mL h-IFN-gamma when tested using KG-1 cell line, corresponding to a specific activity of > 500 units/mg.
Molecular Mass : 18.4 kDa, observed by reducing SDS-PAGE.
Protein Length : 159
AA Sequence : MHFGRLHCTTAVIRSINDQVLFVDK RNPPVFEDMPDIDRTANESQTRLII YMYKDSEVRGLAVTLSVKDGRMSTL SCKNKIISFEEMNPPENIDDIKSDL IFFQKRVPGHNKMEFESSLYEGHFL ACQKEDDAFKLVLKRKDENGDKSVM FTLTNLHQS
Endotoxin : < 0.2 EU/μg, determined by LAL method.
Purity : > 95% by SDS-PAGE analyses.
Storage : Lyophilized recombinant ratInterleukin-18 (rrIL-18) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rrIL-18 should be stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade.
Storage Buffer : Lyophilized after extensive dialysis against 50mM Tris, 50mM NaCl, pH8.0.
Reconstitution : Reconstituted in ddH2O at 100 μg/mL.
Gene Name : Il18 interleukin 18 [ Rattus norvegicus ]
Official Symbol : Il18
Synonyms : IL18; interleukin 18; interleukin-18; IL-1 gamma; interleukin-1 gamma; IFN-gamma-inducing factor; interferon gamma-inducing factor; interferon-gamma-inducing factor; IL-18;
Gene ID : 29197
mRNA Refseq : NM_019165
Protein Refseq : NP_062038
UniProt ID : P97636

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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