Recombinant Human MAP3K14, GST-tagged

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Recombinant Human MAP3K14, GST-tagged

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Cat. No. : MAP3K14-556H
Product Overview : Recombinant Human MAP3K14 (a.a. 381-end) with N-terminal GST tag expressed in aBaculovirus infected Sf9 cellexpression system. MW = 96 kDa.
Description : Mitogen-activated protein kinase kinase kinase 14 is an enzyme that in humans is encoded by the MAP3K14 gene. This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.
Source : Baculovirus infected Sf9 cell.
Application : Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Purity : >90%.
Formulated In : 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 50% glycerol, and 3 mM DTT.
Specific Activity : 20 nM NIK yields 20% conversion of 1 uM [32P]ATP using MBP as substrate. Reaction condition: 10 mM HEPES, pH 7.4, 5 mM MgCl2, 10 μM MnCl2, 1 mM DTT, 3 μM Na-orthovanadate, 1 μM ATP, and MBP as substrate at room temperature for 2 hrs.
Stability : >6 months at -80°C.
Gene Name : MAP3K14 mitogen-activated protein kinase kinase kinase 14 [ Homo sapiens ]
Synonyms : mitogen-activated protein kinase kinase kinase 14; HS; NIK; HSNIK; FTDCR1B; MAP3K14; NF-kappa-beta-inducing kinase; serine/threonine protein-kinase; serine/threonine-protein kinase NIK; EC 2.7.11.25; Serine/threonine-protein kinase NIK
Gene ID : 9020
mRNA Refseq : NM_003954.2
Protein Refseq : NP_003945.2
MIM : 604655
UniProt ID : Q99558
Chromosome Location : 17q21
Pathway : Apoptosis; Epithelial cell signaling in Helicobacter pylori infection; Intestinal immune network for IgA production; MAPK signaling pathway; T cell receptor signaling pathway
Function : MAP kinase kinase kinase activity; ATP binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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