Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged


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Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged

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Cat. No. : IL3-604H
Product Overview : Recombinant humanIL3 is a globular protein consisting of 133 amino acid residues and a 16 asHQ tag. Total length is 149 aa.
Description : IL-3 stimulates thedifferentiation of multipotent hematopoietic stem cells into myeloidprogenitor cells (as opposed to lymphoid progenitor cells wheredifferentiation is stimulated by IL-7) as well as stimulates proliferation ofall cells in the myeloid lineage (erythrocytes, megakaryocytes, granulocytes,monocytes, and dendritic cells). It is secreted by basophils and activated Tcells to support growth and differentiation of T cells from the bone marrowin an immune response.
Source : Hordeum vulgare(barley grain)
Species : Human
Form : Lyophilized from a0.2 um sterile filtered solution of PBS, pH 7.2.
Molecular Weight : 17.2 kDa. Theglycosylated protein migrates with an apparent MW=22 kDa in SDS-PAGE.
Purity : >95% by SDS-PAGE.Purified product carries no pyrogenic or pro-inflammatory contaminants, asassayed with monocyte activation test using custom human Multiplex CytokineAssay measuring IL-6, TNF-alpha and IL-1beta induction.
Endotoxin Level : <0.005 ng per ugof product (0.05 EU/ug) as measured by turbidimetric kinetic assay.
Biological Activity : Bioactivity isassayed by measuring the dose dependent effect of human IL3 on proliferationof TF-1 cells. The ED50 for this batch of recombinant human IL3 is 0.97ng/ml.
Specific Activity : 1.03 x 106 units/mg
Reconstitution : Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration not less than 100 ug/ml. Aftercomplete solubilization of the protein, it can be further diluted to otheraqueous solutions.
Storage : The lyophilizedprotein, though stable at room temperature for two weeks, is best stored at-20°C. Reconstituted protein should be used immediately or stored in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : IL3
Gene Name : IL3 interleukin 3(colony-stimulating factor, multiple) [ Homo sapiens ]
Synonyms : IL3; interleukin 3(colony-stimulating factor, multiple); mIL-3; MCGF; MGC79398; MGC79399;MULTI-CSF; interleukin-3; OTTHUMP00000065963; mast cell growth factor; mast-cellgrowth factor; P-cell stimulating factor; P-cell-stimulating factor; hematopoieticgrowth factor; multilineage-colony-stimulating factor; multipotentialcolony-stimulating factor
Gene ID : 3562
mRNA Refseq : NM_000588
Protein Refseq : NP_000579
MIM : 147740
UniProt ID : P08700
Chromosome Location : 5q23-q31
Pathway : Apoptosis; Asthma; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+TCR pathway; Cytokine Signaling in Immune system; Cytokine-cytokine receptorinteraction; Fc epsilon RI signaling pathway; Hematopoietic cell lineage; IL-3Signaling Pathway; Immune System; Interleukin receptor SHC signaling; Interleukin-2signaling; Interleukin-3, 5 and GM-CSF signaling; Jak-STAT signaling pathway;Signaling by Interleukins
Function : cytokine activity; growthfactor activity; interleukin-3 receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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