Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged IL3-604H

Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged

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Recombinant Human Interleukin 3 (colony-stimulating factor, multiple), HQ-tagged

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Cat. No. : IL3-604H
Product Overview : Recombinant humanIL3 is a globular protein consisting of 133 amino acid residues and a 16 asHQ tag. Total length is 149 aa.
Description : IL-3 stimulates thedifferentiation of multipotent hematopoietic stem cells into myeloidprogenitor cells (as opposed to lymphoid progenitor cells wheredifferentiation is stimulated by IL-7) as well as stimulates proliferation ofall cells in the myeloid lineage (erythrocytes, megakaryocytes, granulocytes,monocytes, and dendritic cells). It is secreted by basophils and activated Tcells to support growth and differentiation of T cells from the bone marrowin an immune response.
Source : Hordeum vulgare(barley grain)
Species : Human
Form : Lyophilized from a0.2 um sterile filtered solution of PBS, pH 7.2.
Molecular Weight : 17.2 kDa. Theglycosylated protein migrates with an apparent MW=22 kDa in SDS-PAGE.
Purity : >95% by SDS-PAGE.Purified product carries no pyrogenic or pro-inflammatory contaminants, asassayed with monocyte activation test using custom human Multiplex CytokineAssay measuring IL-6, TNF-alpha and IL-1beta induction.
Endotoxin Level : <0.005 ng per ugof product (0.05 EU/ug) as measured by turbidimetric kinetic assay.
Biological Activity : Bioactivity isassayed by measuring the dose dependent effect of human IL3 on proliferationof TF-1 cells. The ED50 for this batch of recombinant human IL3 is 0.97ng/ml.
Specific Activity : 1.03 x 106 units/mg
Reconstitution : Centrifuge vialprior to opening. First add sterile distilled water to the vial to fullysolubilize the protein to a concentration not less than 100 ug/ml. Aftercomplete solubilization of the protein, it can be further diluted to otheraqueous solutions.
Storage : The lyophilizedprotein, though stable at room temperature for two weeks, is best stored at-20°C. Reconstituted protein should be used immediately or stored in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
OfficialSymbol : IL3
Gene Name : IL3 interleukin 3(colony-stimulating factor, multiple) [ Homo sapiens ]
Synonyms : IL3; interleukin 3(colony-stimulating factor, multiple); mIL-3; MCGF; MGC79398; MGC79399;MULTI-CSF; interleukin-3; OTTHUMP00000065963; mast cell growth factor; mast-cellgrowth factor; P-cell stimulating factor; P-cell-stimulating factor; hematopoieticgrowth factor; multilineage-colony-stimulating factor; multipotentialcolony-stimulating factor
Gene ID : 3562
mRNA Refseq : NM_000588
Protein Refseq : NP_000579
MIM : 147740
UniProt ID : P08700
Chromosome Location : 5q23-q31
Pathway : Apoptosis; Asthma; Calcineurin-regulatedNFAT-dependent transcription in lymphocytes; Calcium signaling in the CD4+TCR pathway; Cytokine Signaling in Immune system; Cytokine-cytokine receptorinteraction; Fc epsilon RI signaling pathway; Hematopoietic cell lineage; IL-3Signaling Pathway; Immune System; Interleukin receptor SHC signaling; Interleukin-2signaling; Interleukin-3, 5 and GM-CSF signaling; Jak-STAT signaling pathway;Signaling by Interleukins
Function : cytokine activity; growthfactor activity; interleukin-3 receptor binding

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