Recombinant Human Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1, GST-tagged

• Cat.No.: RPS6KB1-5478H
• Product Overview: Recombinant humanRPS6KB1 catalytic domain (amino acids 1-421), GST-tagged. Activated in vitroby His-tagged PDK1.

Specification

• Cat. No.: RPS6KB1-5478H
• Description: Thisgene encodes a member of the RSK (ribosomal s6 kinase) family ofserine/threonine kinases. This kinase contains 2 non-identical kinasecatalytic domains and phosphorylates several residues of the S6 ribosomalprotein. The kinase activity of this protein leads to an increase in proteinsynthesis and cell proliferation.
• Source: Insect cells
• Species: Human
• Form: Liquid in 50 mMTris, pH 7.5 + 150 mM NaCl + 0.5 mM EDTA + 0.02% Triton X-100 + 2 mM DTT +50% glycerol.
• MolecularWeight: 75.1 kDa
• Storage: Stable for 6 monthsin working aliquots at -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: RPS6KB1
• Pathways: Acute myeloidleukemia; Angiopoietin receptor Tie2-mediated signaling; B Cell ReceptorSignaling Pathway; CDC42 signaling events; Cytoplasmic Ribosomal Proteins;ErbB signaling pathway; Fc gamma R-mediated phagocytosis; G13 SignalingPathway; IGF1 pathway; IL-2 Signaling Pathway; IL-4 signaling Pathway; IL-6 SignalingPathway; IL2 signaling events mediated by; IL4-mediated signaling events;IRS-mediated signalling

Gene Information

• Gene Name: RPS6KB1 ribosomal protein S6kinase, 70kDa, polypeptide 1 [ Homo sapiens ]
• Synonyms: RPS6KB1; ribosomalprotein S6 kinase, 70kDa, polypeptide 1; S6K; PS6K; S6K1; STK14A; p70-S6K;p70-alpha; p70(S6K)-alpha; ribosomal protein S6 kinase beta-1; P70S6K1;p70 S6KA; S6K-beta-1; p70 S6K-alpha; OTTHUMP00000198109; OTTHUMP00000198110;p70 S6 kinase, alpha 1; p70 S6 kinase, alpha 2; ribosomal protein S6 kinase I;serine/threonine kinase 14 alpha; serine/threonine-protein kinase 14A; 70 kDaribosomal protein S6 kinase 1; EC 2.7.11.1; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase14A
• Gene ID: 6198
• mRNA Refseq: NM_003161
• Protein Refseq: NP_003152
• MIM: 608938
• UniProt ID: P23443
• Chromosome Location: 17q23.1
• Function: ATP binding;nucleotide binding; peptide binding; protein binding; protein kinaseactivity; protein serine/threonine kinase activity; ribosomal protein S6kinase activity