Recombinant Human Transforming Growth Factor, Alpha


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Recombinant Human Transforming Growth Factor, Alpha

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Cat. No. : TGFA-5521H
Product Overview : Recombinant Human TGFAcomprises the human TGF-alpha amino acid sequence plus a 14 amino acidN-terminal extension peptide.
Description : This product is alow cost, potent analog of human TGF-alpha. The recombinant growth factor canbe used as a supplement for serum-free or low serum cell culture. It is alsosuitable for cultured fibroblasts, particularly from avian species used inthe production of viral vaccines.
Source : E. coli
Species : Human
Form : Lyophilized whitepowder. Dried from 0.1 M acetic acid and stored under nitrogen at a slightvacuum.
Purity : > 90% (byN-terminal sequence analysis).
Molecular Weight : 7113Daltons-confirmed by Mass Spectrometry (minor N-terminal formylated form of7142 Daltons).
N-terminal SequenceAnalysis : 18 residues > 96% single sequence.
Biological Activity : Cell proliferationin Balb/c 3T3 fibroblasts: ED50 <20 ng/ml (in the presence of100 ng/ml Long TMR3IGF-I).
Endotoxin : < 0.1 EU/μg
Reconstitution : Handling of GroPepLONG™EGF and LONG™TGF-α.
Storage : At least 2 years at2 - 4°C (lyophilized).
OfficialSymbol : TGFA
Pathways : Direct p53effectors; ErbB receptor signaling network; ErbB signaling pathway; FOXM1transcription factor network; Glioma; Non-small cell lung cancer; Pancreaticcancer; Pathways in cancer; Prostate cancer; Renal cell carcinoma
Gene Name : TGFA transforming growth factor,alpha [ Homo sapiens ]
Synonyms : TGFA; transforminggrowth factor, alpha; TFGA; protransforming growth factor alpha;TGF-alpha; OTTHUMP00000160075; OTTHUMP00000203300; OTTHUMP00000203301;OTTHUMP00000203345; OTTHUMP00000203352; OTTHUMP00000225517; Protransforming growth factor alpha;Transforming growth factor alpha
Gene ID : 7039
mRNA Refseq : NM_001099691
Protein Refseq : NP_001093161
MIM : 190170
UniProt ID : P01135
Chromosome Location : 2p13
Function : MAP kinase kinaseactivity; epidermal growth factor receptor binding; glycoprotein binding;growth factor activity; protein binding; signal transducer activity

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