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Recombinant Human Transforming Growth Factor, Alpha

Cat.No. : TGFA-5521H
Product Overview : Recombinant Human TGFAcomprises the human TGF-alpha amino acid sequence plus a 14 amino acidN-terminal extension peptide.
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Cat. No. : TGFA-5521H
Description : This product is alow cost, potent analog of human TGF-alpha. The recombinant growth factor canbe used as a supplement for serum-free or low serum cell culture. It is alsosuitable for cultured fibroblasts, particularly from avian species used inthe production of viral vaccines.
Source : E. coli
Species : Human
Form : Lyophilized whitepowder. Dried from 0.1 M acetic acid and stored under nitrogen at a slightvacuum.
Purity : > 90% (byN-terminal sequence analysis).
Molecular Weight : 7113Daltons-confirmed by Mass Spectrometry (minor N-terminal formylated form of7142 Daltons).
N-terminal SequenceAnalysis : 18 residues > 96% single sequence.
Biological Activity : Cell proliferationin Balb/c 3T3 fibroblasts: ED50 <20 ng/ml (in the presence of100 ng/ml Long TMR3IGF-I).
Endotoxin : < 0.1 EU/μg
Reconstitution : Handling of GroPepLONG™EGF and LONG™TGF-α.
Storage : At least 2 years at2 - 4°C (lyophilized).
OfficialSymbol : TGFA
Pathways : Direct p53effectors; ErbB receptor signaling network; ErbB signaling pathway; FOXM1transcription factor network; Glioma; Non-small cell lung cancer; Pancreaticcancer; Pathways in cancer; Prostate cancer; Renal cell carcinoma
Gene Name : TGFA transforming growth factor,alpha [ Homo sapiens ]
Synonyms : TGFA; transforminggrowth factor, alpha; TFGA; protransforming growth factor alpha;TGF-alpha; OTTHUMP00000160075; OTTHUMP00000203300; OTTHUMP00000203301;OTTHUMP00000203345; OTTHUMP00000203352; OTTHUMP00000225517; Protransforming growth factor alpha;Transforming growth factor alpha
Gene ID : 7039
mRNA Refseq : NM_001099691
Protein Refseq : NP_001093161
MIM : 190170
UniProt ID : P01135
Chromosome Location : 2p13
Function : MAP kinase kinaseactivity; epidermal growth factor receptor binding; glycoprotein binding;growth factor activity; protein binding; signal transducer activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does TGFA contribute to cell growth and proliferation? 05/10/2022

It stimulates cell proliferation and survival, playing a key role in tissue development.

How do genetic variations in TGFA affect tissue repair? 12/27/2020

Genetic mutations in TGFA can lead to impaired wound healing and tissue regeneration.

What is the impact of altered TGFA activity on cancer development? 11/09/2019

Altered TGFA activity is linked with cancer progression, as it can stimulate uncontrolled cell growth.

What is the primary role of TGFA in cell signaling? 01/29/2018

TGFA, a growth factor, is vital for activating signaling pathways that control cell growth and differentiation.

What potential therapeutic applications arise from targeting TGFA in regenerative medicine and oncology? 06/22/2017

Targeting TGFA offers potential for treating wounds and cancer by modulating growth factor signaling.

How does TGFA interact with other growth factors and receptors? 06/12/2017

TGFA interacts with epidermal growth factor receptors, influencing various cellular processes.

What role does TGFA play in wound healing? 03/14/2017

TGFA is important in wound healing, promoting the regeneration of skin and other tissues.

Customer Reviews (3)

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Reviews
05/03/2020

    Swift and accurate service, essential for research success.

    04/14/2020

      Invaluable support for insights, a research cornerstone.

      12/21/2018

        Trustworthy results, supports research consistency.

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