"TNFRSF11B" Related Products

Recombinant Human Tumor Necrosis Factor Receptor Superfamily, Member 11b

Cat. No.: TNFRSF11B-5526H
Product Overview: Recombinant human TNFRSF11Bis a 20 kDa protein, comprising of 174 amino acid residues.
Description: Human TNFRSF11B(Osteoprotegerin), also known as OCIF (Osteoclastogenesis inhibitory factor),is a member of the TNF receptor superfamily. Recombinant human OPG/OCIF specificallyacts on bone tissues and increases bone mineral density and bone volumeassociated with a decrease of active osteoclast number.
Source: E. coli
Species: Human
Form: Sterile filtered andthen lyophilized from 10 mM Tris, pH 7.5 + 75 mM NaCl.
MolecularWeight: 20 kDa
Purity: >98% by SDS-PAGEand HPLC analyses
Endotoxin Level: < 0.1 ng/µg
Biological Activity: Determined by itsability to neutralize the stimulation of U937 cells treated with 10 ng/ml ofsRANKL.
Reconstitution: Centrifuge the vialprior to opening. Reconstitute in 5 mM Tris, pH 7.5 to a concentration of0.1-1.0 mg/ml. The solution can be diluted into other aqueous buffers andstored at 2-4°C for 1 week or -20°C for future use. Avoid repeatedfreeze-thaw cycles.
Storage: The lyophilizedhuman OPG should be stored desiccated below 0°C. Reconstituted human OPGshould be stored in working aliquots at -20°C.
OfficialSymbol: TNFRSF11B
Gene Name: TNFRSF11B tumor necrosis factorreceptor superfamily, member 11b [ Homo sapiens ]
Synonyms: TNFRSF11B; tumornecrosis factor receptor superfamily, member 11b; OPG; TR1; OCIF; MGC29565;tumor necrosis factor receptor superfamily member 11B; osteoprotegerin;Osteoprotegerin; OTTHUMP00000228056; osteoclastogenesis inhibitory factor;Osteoclastogenesis inhibitory factor
Gene ID: 4982
mRNA Refseq: NM_002546
Protein Refseq: NP_002537
MIM: 602643
UniProt ID: O00300
Chromosome Location: 8q24
Pathway: Cytokine-cytokinereceptor interaction; Monoamine Transport; Osteoblast Signaling; Osteoclastdifferentiation
Function: binding; cytokineactivity; receptor activity

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