Recombinant Human Fms-Related Tyrosine Kinase 3

Cat. No.: FLT3-1225H
Product Overview: Recombinant humanFLT3 is Expressed in HEK 293 cells.
Description: FLT3 Ligand is expressed from human 293cells as a monomeric glycoprotein with an apparent MW 24 to 30 kDa. Thiscytokine is produced in a serum-free, chemically defined media. The molecularmass is a narrower range than reported when this cytokine is expressed ininsect Sf21 cells (17 to 30 kDa), emphasizing the difference in glycosylationin different expression systems.
Source: HEK 293 cells
Species: Human
MolecularWeight: 24 to 30 kDamonomer, glycosylated
Purity: > 95% The proteinwas resolved by SDS polyacrylamide gel electrophoresis and the gel wasstained with Coomassie blue.
Endotoxin Level: Endotoxin Free <1EU/ug
Biological Activity: 0.2 to 0.8 ng/mLED50
Storage: The specificactivity was determined by the dose-dependent stimulation of theproliferation of the human acute myeloid leukemia cell line OCI-AML5.
Gene Name: FLT3 fms-related tyrosine kinase 3 [ Homosapiens ]
Official Symbol: FLT3
Synonyms: FLT3; fms-related tyrosinekinase 3; FLK2; STK1; CD135; CD135 antigen; fetal liver kinase 2; FL cytokinereceptor; tal liver kinase 2; stem cell tyrosine kinase 1; FLT3 receptortyrosine kinase; tyrosine-protein kinase receptor FLT3; growth factorreceptor tyrosine kinase type III; C 2.7.10.1; OTTHUMP00000042340; fetalliver kinase 2
Gene ID: 2322
mRNA Refseq: NM_004119
Protein Refseq: NP_004110
MIM: 136351
UniProt ID: P36888
Chromosome Location: 13q12
Pathway: Acute myeloidleukemia; Cytokine-cytokine receptor interaction; Hematopoietic cell lineage;Pathways in cancer
Function: ATP binding; nucleotidebinding; osphoinositide 3-kinase binding; protein binding; receptor activity;transferase activity; vascular endothelial growth factor receptor activity

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