Cat. No. :	IGF2-692H
Product Overview :	Recombinant humanIGF2 was expressed in E. coli.
Description :	Human [Leu27]IGF-II is an analog of human IGF-II which has Leu in place of Tyr at position27. Of the IGF-II amino acid sequence. Compared to human IGF-II, human [Leu27]IGF-II has a 10-20 fold reduced affinity for the Type 1 IGF receptor.
Source :	E. coli
Species :	Human
Purity :	Greater than 95% (byHPLC and N-terminal sequence analysis).
Molecular Weight :	7.420 kDa-confirmedby Mass Spectometry.
Endotoxin Level :	Less than 0.1 EU/ug
Biological Activity :	Type 1 IGF receptorbinding assay: ED50>175 ng/ml. Type 2 IGF receptor binding assay:ED50<371 ng/ml. IGF binding protein assay: ED50<10 ng/ml.
State and appearance :	Lyophilized whitepowder. Dried from 0.1 M acetic acid and stored under dry nitrogen at aslight vacuum (-25 kPa).
N-terminal sequenceanalysis :	5 residues Greaterthan 95% single sequence.
Reconstitution :	Refer to Protocol 1000:Handling of GroPep IGF-I, IGF-II and IGF Analogs.
Storage :	At least 2 years at2-4°C (lyophilized).
OfficialSymbol :	IGF2

Gene Name :	IGF2 insulin-like growth factor2 (somatomedin A) [ Homo sapiens ]
Synonyms :	IGF2; insulin-likegrowth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734;insulin-like growth factor II;somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015;OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158;OTTHUMP00000220677; insulin-like growth factor type 2
Gene ID :	3481
mRNA Refseq :	NM_000612
Protein Refseq :	NP_000603
MIM :	147470
UniProt ID :	P01344
Chromosome Location :	11p15
Pathway :	Apoptosis;Diabetes pathways; Endochondral Ossification; Hedgehog Signaling Pathway;Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-likeGrowth Factor Binding Proteins (IGFBPs)
Function :	growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; protein binding; protein serine/threoninekinase activator activity; receptor activator activity

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