Cat. No. : | IGF2-692H |
Product Overview : | Recombinant humanIGF2 was expressed in E. coli. |
Description : | Human [Leu27]IGF-II is an analog of human IGF-II which has Leu in place of Tyr at position27. Of the IGF-II amino acid sequence. Compared to human IGF-II, human [Leu27]IGF-II has a 10-20 fold reduced affinity for the Type 1 IGF receptor. |
Source : | E. coli |
Species : | Human |
Purity : | Greater than 95% (byHPLC and N-terminal sequence analysis). |
Molecular Weight : | 7.420 kDa-confirmedby Mass Spectometry. |
Endotoxin Level : | Less than 0.1 EU/ug |
Biological Activity : | Type 1 IGF receptorbinding assay: ED50>175 ng/ml. Type 2 IGF receptor binding assay:ED50<371 ng/ml. IGF binding protein assay: ED50<10 ng/ml. |
State and appearance : | Lyophilized whitepowder. Dried from 0.1 M acetic acid and stored under dry nitrogen at aslight vacuum (-25 kPa). |
N-terminal sequenceanalysis : | 5 residues Greaterthan 95% single sequence. |
Reconstitution : | Refer to Protocol 1000:Handling of GroPep IGF-I, IGF-II and IGF Analogs. |
Storage : | At least 2 years at2-4°C (lyophilized). |
OfficialSymbol : | IGF2 |
Gene Name : | IGF2 insulin-like growth factor2 (somatomedin A) [ Homo sapiens ] |
Synonyms : | IGF2; insulin-likegrowth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734;insulin-like growth factor II;somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015;OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158;OTTHUMP00000220677; insulin-like growth factor type 2 |
Gene ID : | 3481 |
mRNA Refseq : | NM_000612 |
Protein Refseq : | NP_000603 |
MIM : | 147470 |
UniProt ID : | P01344 |
Chromosome Location : | 11p15 |
Pathway : | Apoptosis;Diabetes pathways; Endochondral Ossification; Hedgehog Signaling Pathway;Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-likeGrowth Factor Binding Proteins (IGFBPs) |
Function : | growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; protein binding; protein serine/threoninekinase activator activity; receptor activator activity |
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