Recombinant Human Interleukin 4 Receptor

• Cat.No.: IL4R-1238H
• Product Overview: Recombinant human IL4Ris a 23.7 kDa protein containing 207 amino acid residues consisting of onlythe extracellular domain of the IL4R.

Specification

• Cat. No.: IL4R-1238H
• Description: HumanIL-4 exerts its biological effects via signaling through its receptor system,IL4R. There are two types of the IL4R complexes, the type I receptorconsisting of the IL4R alpha and the common gamma chain, yc and the type IIreceptor consisting of IL4R and the IL-13R alpha. The IL4R chain contains anextracellular domain of 207 amino acids, a transmembrane domain of 24 aminoacids, and an intracellular domain of 569 amino acids.
• Source: A293 cells
• Species: Human
• Form: Lyophilized
• Purity: Greater than 97% bySDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per ug(1EU/ug).
• Biological Activity: The ED50was determined by its ability to inhibit the IL-4 dependent proliferation ofhuman TF-1 cells is < 5.0 ng/ml (in the presence of 0.5 ng/ml of IL-4),corresponding to a specific activity of > 2 x 105 units/mg.
• Reconstitution: Werecommend a quick spin followed by reconstitution in water to a concentrationof 0.1-1.0 mg/ml. This solution can then be diluted into other aqueousbuffers and stored at 40°C for 1 week or -200°C forfuture use.
• storage: Thelyophilized protein is stable for a few weeks at room temperature, but beststored at -200°C. Reconstituted IL4R alpha should be storedin working aliquots at -200°C.
• OfficialSymbol: IL4R

Gene Information

• Gene Name: IL4R interleukin 4 receptor [ Homosapiens ]
• Synonyms: IL4R; interleukin 4 receptor;CD124; IL4RA; OTTHUMP00000122506; interleukin 4 receptor alpha chain;interleukin-4 receptor alpha chain; IL-4R-alpha; CD124 antigen
• Gene ID: 3566
• mRNA Refseq: NM_000418
• Protein Refseq: NP_000409
• MIM: 147781
• UniProt ID: P24394
• Chromosome Location: 16p12.1-p11.2
• Pathway: Cytokine-cytokine receptorinteraction; Jak-STAT signaling pathway; Hematopoietic cell lineage
• Function: interleukin-4 receptoractivity; receptor activity; protein binding; receptor signaling proteinactivity