"FCN2" Related Products


Recombinant Human Ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), His-tagged

Cat. No. : FCN2-494H
Product Overview : Recombinant Human FCN2is expressed in Murine myeloma cell line, which has a molecule weight of 32.8kDa. Leu26 ­ Ala313, with a C­terminal 10­His tag.
Description : Human Ficolin­2 (fibrinogen/collagen­like;previously called L­ficolin or ficolin­B) is a member of the ficolin family ofsecreted pattern recognition proteins that participate in the lectin complementactivation pathway. Ficolin­2 is expressed in the liver and released into thecirculation. The 35 ­ 40 kDa, 313 amino acid (aa) human Ficolin­2 contains a 25aa signal sequence, an N­terminal collagen domain and a C­terminal fibrinogen­likedomain that includes a calcium binding site and two potential N­glycosylationsites. The collagen domain mediates trimer formation. Larger homo­multimers areformed by disulfide links at the N­terminus, the most prominent of which is a12 subunit oligomer. Ficolin­2 binds microbial ligands that contain acetylatedcompounds. Mature human Ficolin­2 shares 70%, 72%, 76% and 78% aa identity withmouse, rat, cow and pig Ficolin­2, respectively. It shares 84% and 52% aa identitywith human ficolin­1 and ficolin­3, respectively. Single nucleotide polymorphismsare common in human Ficolin­2. Some affect serum concentration, while others canincrease or decrease ligand binding.
Source : Murine myeloma cell line,NS0­derived
Form : Lyophilized from a 0.2μm filtered solution in PBS.
N-terminal Sequence : Leu26
Molecular Weight : 32.8 kDa
Activity : Measured by its abilityto bind biotinylated N­Acetylglucosamine­Polyacrylamide in a functional ELISA.
Purity : >95%, by SDS­PAGEunder reducing conditions and visualized by silver stain.
Endotoxin Level : <1.0 EU per 1 μg ofthe protein by the LAL method.
Reconstitution : Reconstitute at 100 μg/mLin PBS.
Storage : Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt,-20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to -70 °C under sterile conditions after reconstitution.
OfficialSymbol : FCN2
PDB rendering based on2j0g. :

Gene Name : FCN2 ficolin (collagen/fibrinogendomain containing lectin) 2 (hucolin) [ Homo sapiens ]
Synonyms : FCN2; ficolin (collagen/fibrinogendomain containing lectin) 2 (hucolin); P35; FCNL; EBP-37; ficolin-2; L-ficolin;ficolin B; ficolin-B; ficolin-beta; serum lectin p35; Hucolin; 37 kDa elastin-bindingprotein; collagen/fibrinogen domain-containing protein 2; OTTHUMP00000022518
Gene ID : 2220
mRNA Refseq : NM_004108
Protein Refseq : NP_004099
MIM : 601624
UniProt ID : Q15485
Chromosome Location : 9q34.3
Function : antigen binding; calciumion binding; calcium-dependent protein binding; receptor binding; sugar binding

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