"IL18" Related Products

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Recombinant Human Interleukin 18

Cat. No.: IL18-433H
Product Overview: Interleukin-18 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids and having a molecular mass of 18302 Dalton. The IL-18 is purified by proprietary chromatographic techniques.
Description: IL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity.
Source: Human
Host: Escherichia Coli.
Form: Lyophilized from a concentrated (1mg/ml) solution in water containing 0.5x PBS pH=7.3.
Purity: Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Bio-activity: The ED50 as determined by the dose-dependant stimulation of the IFN-g by human PBMC co-stimulated with IL-12 was found to be 5ng/ml corresponding to a Specific Activity of 200,000IU/mg.
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility: It is recommended to reconstitute the lyophilized Interleukin 18 in sterile 18Mμ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Storage: Lyophilized Interleukin 18 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL18 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Pathways: African trypanosomiasis; Cellular roles of Anthrax toxin; Cytokine Signaling in Immune system; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway; Hypertrophy Model; IL12 signaling mediated by STAT4; IL12-mediated signaling events; Immune System; Influenza A; Interleukin-1 processing; Malaria; NOD-like receptor signaling pathway; Rheumatoid arthritis; Signaling by Interleukins; Tuberculosis
Gene Name: IL18 interleukin 18 (interferon-gamma-inducing factor) [ Homo sapiens ]
Official Symbol: IL18
Synonyms: Interferon-gamma-inducing factor; IGIF; IL-1g; IL-18; IL1F4; MGC12320; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; Iboctadekin; IL18
Gene ID: 3606
mRNA Refseq: NM_001562
Protein Refseq: NP_001553
MIM: 600953
UniProt ID: Q14116
Chromosome Location: 11q22.2-q22.3
Function: cytokine activity; signal transducer activity

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