Recombinant Human Interleukin 1 Family, Member 6 (Epsilon)


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Recombinant Human Interleukin 1 Family, Member 6 (Epsilon)

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Cat. No. : IL1F6-398H
Product Overview : IL1F6 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 158 amino acids and having a molecular mass of 17.7kDa. The IL1F6 is purified by proprietary chromatographic techniques.
Description : Human interleukin family 1, member 6 (hIL-1F6 / FIL1-epsilon) belongs to the interleukin 1 cytokine family. IL1F6 is expressed in the immune system and the fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. IL1F6 is the only IL-1 family member found to be expressed on T-cells. IL1F6 functions via receptor complex of IL-1Rrp2 and IL-1RAcP. The recombinant IL1F6, along with IL1F8 and IL1F9, acts as an agonist by activating the pathway involving NF?B and MAPK in an IL-1Rrp2 dependent manner.
Source : Human
Host : Escherichia Coli.
Form : IL1F6 was lyophilized after extensive dialysis against 20mM Phosphate buffer, pH7.4.
Purity : Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Bio-activity : As measured by its binding ability in a functional ELISA, immobilized IL1F6 at 1 µg/ml (100 µl/well) can bind rHuIL-1 Rrp2/Fc Chimera with a linear range of 0.15- 5 µg/ml.
Physical Appearance : Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility : It is recommended to quick spin followed by reconstitution of IL1F6 in PBS to a concentration no less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Amino acid sequence : The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Lys-Ala-Leu.
Storage : Lyophilized IL1F6 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL1F6 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.
Gene Name : IL1F6 interleukin 1 family, member 6 (epsilon) [ Homo sapiens ]
Official Symbol : IL1F6
Synonyms : IL1F6; interleukin 1 family, member 6 (epsilon); FIL1; FIL1E; IL-1F6; MGC129552; MGC129553; IL1(EPSILON); FIL1(EPSILON); IL-1F6 (FIL-1-epsilon); interleukin 1, epsilon; Interleukin-1 family member 6; Interleukin-1 epsilon; IL-1 epsilon; FIL1 epsilon
Gene ID : 27179
mRNA Refseq : NM_014440
Protein Refseq : NP_055255
MIM : 605509
UniProt ID : Q9UHA7
Chromosome Location : 2q12-q14.1
Function : cytokine activity; interleukin-1 receptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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