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| Cat. No.: | PRDX2-1438H |
| Product Overview: | PRDX2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 198 amino acids and having a molecular mass of 21.8 kDa. The PRDX2 is purified by proprietary chromatographic techniques. |
| Description: | PRDX2 is part of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX2 takes part as an antioxidant protective role in cells. T-cells. PRDX2 has proliferative effect in cancer development or progression. If PRDX2 protection is insufficient against peroxidases, the DNA damage results in neurological disease such as Alzheimer"s or DNA damage leading to cancer. |
| Source: | Human |
| Host: | Escherichia Coli. |
| Form: | The Peroxiredoxin solution contains 20 mM Tris-HCl pH-8, & 10% glycerol. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Bio-activity: | The specific activity was found to be approximately 200-230 pmole/min/µg. The enzymatic activity was confirmed by measuring the remaining peroxide after incubation of PRDX2 and peroxide for 20 min at room temperature. Specific activity is defined as the amount of hydroperoxide that 1 ug of enzyme can reduce at 25°C for 1 minute. |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Amino acid sequence: | MASGNARIGK PAPDFKATAV VDGAFKEVKL SDYKGKYVVL FFYPLDFTFV CPTEIIAFSN RAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTRR LSEDYGVLKT DEGIAYRGLF IIDGKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN |
| Storage: | PRDX2 although stable 4°C for 4 weeks, should be stored desiccated below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles. |
| Gene Name: | PRDX2 peroxiredoxin 2 [ Homo sapiens ] |
| Official Symbol: | PRDX2 |
| Synonyms: | PRDX2; peroxiredoxin 2; PRP; TSA; PRX2; TPX1; NKEFB; PRXII; TDPX1; MGC4104; peroxiredoxin-2; torin; NKEF-B; OTTHUMP00000165823; OTTHUMP00000165825; thioredoxin peroxidase 1; thiol-specific antioxidant 1; natural killer-enhancing factor B; thiol-specific antioxidant protein ;natural killer cell-enhancing factor B; thioredoxin-dependent peroxide reductase 1 |
| Gene ID: | 7001 |
| mRNA Refseq: | NM_005809 |
| Protein Refseq: | NP_005800 |
| MIM: | 600538 |
| UniProt ID: | P32119 |
| Chromosome Location: | 19p13 |
| Pathway: | Selenium Pathway |
| Function: | antioxidant activity; oxidoreductase activity; thioredoxin peroxidase activity |
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