Recombinant Human Thrombopoietin
Cat.No. : | THPO-1533H |
Product Overview : | Recombinant human rhTPO contains no μTagsμ and has a calculated MW of 37.4kDa. Asaresult of glycosylation, DTT-reduced protein migrates as a 60-80 kDa polypeptide in SDS-PAGE. |
- Specification
- Gene Information
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Cat. No. : | THPO-1533H |
Description : | Thrombopoietin (THPO) is a relatively lineage-specific cytokine that stimulates megakaryocyte growth and maturation in Thrombopoietin is a relatively lineage specific cytokine that stimulates megakaryocyte growth and maturation in vitro and is a potent in vivo thrombopoietic growth factor. On removal of the 21-amino acid signal peptide, the mature molecule consists of 2 domains: a receptor-binding domain that shows considerable homology to erythropoietin and a carbohydrate-rich carboxy-terminus of the protein that is highly glycosylated and important in maintaining protein stability. |
Source : | Recombinant human TPO/THPO (rhTPO) Met1-Gly349 (Accession AAI30323) was produced in human HEK293 cells. |
Species : | Human |
Form : | Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder Normally 5-8% trehalose and lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization. |
Purity : | >95% as determined by SDS-PAGE. All lots are greater than 95% pure. |
Endotoxin : | Less than 1.0 EU per 1 μg of the rhTPO by the LAL method. |
Storage : | Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles. |
Gene Name : | THPO thrombopoietin [ Homo sapiens ] |
Official Symbol : | THPO |
Synonyms : | THPO; thrombopoietin; thrombopoietin nirs variant 1; megakaryocyte stimulating factor; MKCSF; c-mpl ligand; megakaryocyte colony-stimulating factor; MGDF; megakaryocyte growth and development factor; MPL ligand; myeloproliferative leukemia virus oncogene ligand; C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGC163194; Myeloproliferative leukemia virus oncogene ligand; ML; TPO; MPLLG; OTTHUMP00000210502; OTTHUMP00000210503; OTTHUMP00000210504 |
Gene ID : | 7066 |
mRNA Refseq : | NM_000460 |
Protein Refseq : | NP_000451 |
MIM : | 600044 |
UniProt ID : | P40225 |
Chromosome Location : | 3q27 |
Pathway : | Hematopoietic cell lineage; Formation of Platelet plug; Hemostasis; Platelet Activation; Platelet activation triggers |
Function : | cytokine activity; growth factor activity; hormone activity |
Products Types
◆ Recombinant Protein | ||
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Thpo-895M | Recombinant Mouse Thpo Protein | +Inquiry |
THPO-289H | Recombinant Human THPO Protein (Ser22-Leu195), N-His tagged, Animal-free, Carrier-free | +Inquiry |
Thpo-891R | Recombinant Rat Thpo Protein | +Inquiry |
THPO-4327B | Recombinant Bovine THPO Protein | +Inquiry |
◆ Lysates | ||
THPO-001HCL | Recombinant Human THPO cell lysate | +Inquiry |
THPO-2273CCL | Recombinant Cynomolgus THPO cell lysate | +Inquiry |
THPO-2832HCL | Recombinant Human THPO cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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