| Cat. No.: | THPO-1533H |
| Product Overview: | Recombinant human rhTPO contains no μTagsμ and has a calculated MW of 37.4kDa. Asaresult of glycosylation, DTT-reduced protein migrates as a 60-80 kDa polypeptide in SDS-PAGE. |
| Description: | Thrombopoietin (THPO) is a relatively lineage-specific cytokine that stimulates megakaryocyte growth and maturation in Thrombopoietin is a relatively lineage specific cytokine that stimulates megakaryocyte growth and maturation in vitro and is a potent in vivo thrombopoietic growth factor. On removal of the 21-amino acid signal peptide, the mature molecule consists of 2 domains: a receptor-binding domain that shows considerable homology to erythropoietin and a carbohydrate-rich carboxy-terminus of the protein that is highly glycosylated and important in maintaining protein stability. |
| Source: | Recombinant human TPO/THPO (rhTPO) Met1-Gly349 (Accession AAI30323) was produced in human HEK293 cells. |
| Species: | Human |
| Form: | Bulk protein in a 0.22 μm filtered solution of PBS, pH 7.4 and delivered as liquid formulation or lyophilized powder Normally 5-8% trehalose and lyophilized powder. Normally 5-8% trehalose and mannitol are added as protectants before lyophilization. |
| Purity: | >95% as determined by SDS-PAGE. All lots are greater than 95% pure. |
| Endotoxin: | Less than 1.0 EU per 1 μg of the rhTPO by the LAL method. |
| Storage: | Stable in lyophilized state at 4°C for 1 year after receipt. Sterile stock solutions reconstituted are stable at 4°C for 2 months and at -20°C for 6 months. Avoid repeated freeze-thaw cycles. |
| Gene Name: | THPO thrombopoietin [ Homo sapiens ] |
| Official Symbol: | THPO |
| Synonyms: | THPO; thrombopoietin; thrombopoietin nirs variant 1; megakaryocyte stimulating factor; MKCSF; c-mpl ligand; megakaryocyte colony-stimulating factor; MGDF; megakaryocyte growth and development factor; MPL ligand; myeloproliferative leukemia virus oncogene ligand; C-mpl ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGC163194; Myeloproliferative leukemia virus oncogene ligand; ML; TPO; MPLLG; OTTHUMP00000210502; OTTHUMP00000210503; OTTHUMP00000210504 |
| Gene ID: | 7066 |
| mRNA Refseq: | NM_000460 |
| Protein Refseq: | NP_000451 |
| MIM: | 600044 |
| UniProt ID: | P40225 |
| Chromosome Location: | 3q27 |
| Pathway: | Hematopoietic cell lineage; Formation of Platelet plug; Hemostasis; Platelet Activation; Platelet activation triggers |
| Function: | cytokine activity; growth factor activity; hormone activity |
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