"UGT1A1" Related Products

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Recombinant Human UDP Glucuronosyltransferase 1 Family, Polypeptide A1

Cat. No.: UGT1A1-1118H
Product Overview: Human UGT1A1 (NP_000454, 1 a.a. ~ 154 a.a.) partial recombinant protein expressed in Escheri- chia coli.
Description: UGT-1A is a uridine diphosphate glucuronyltransferase (UDP-glucuronosyltransferase, UDPGT), an enzyme of the glucuronidation pathway that transforms small li- pophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites.
Sequence: MATKAVCVLKGDGPVQG IINFEQKESNGPVKVWGS IKGLTEGLHGFHVHEFGD NTAGCTSGPHFNPLSRKH GGPKDEERHVGDLGNVTA DKDGVADVSIEDSVISLSGD HCIIGRTLVVHEKADDLGKGGN EESTKTGNAGSRLACGVIGIAQ
Theoretical MW (kDa): 15.9
Form: Liquid
Preparation Method: Escherichia coli expression system
Purity: μ 95% by SDS-PAGE
Activity: Specific activity is > 90 units/mg, in which one unit will inhibit the rate of reduction of cytochrome c by 50% in a coupled system, using xanthine and Xanthine oxidase at pH 7.8 at 25°C in a 1.5 ml reaction volume.
Application: SDS-PAGE; Functional Study
Storage Buffer: In 20 mM Tris, pH 7.5 (10% glycerol)
Storage: Store at 4°C for 1~2 weeks. For long term storage store at -20°C or -80°C.Aliquot to avoid repeated freezing and thawing.
Unitprot ID: Q5DT03
Pathways: Ascorbate and aldarate metabolism; Biological oxidants; Drug metabolish-cytochrome P450; Estrogen metabolish; Irinotecan pathway; Metabolish of lipids and lipoproteins; Retinol metabolish; Starch and sucrose metabolish; Steroid hormone biosynthesis; metabolish pathway
Functions: enzyme binding; enzyme inhibitor activity; qlucuronosyltransfersase activity; protein heterodimerization activity; retinoic acid binding; steroid binding
Gene Name: UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 [ Homo sapiens ]
Official Symbol: UGT1A1
Synonyms: UGT1A1; GNT1; UGT1; UDPGT; UGT1A; HUG-BR1; BILIQTL1; UDPGT 1-1; HUG-BR1; UDP glycosyltransferase 1 family, polypeptide A1; UGT1-01; UGT-1A; UGT1*1; UGT1.1; UDP-glucuronosyltransfersae 1-A1; UDPGT 1-1; EC 2.4.1.17; BILIQTL1; Hug-br1; UDP glucuronosyltransferase 1 family, polypeptide A1;Bilirubin-specific UDPGT isozyme 1; UDPGT; UDP-glucuronosyltransfersae 1-A; OTTHUMP000000651199
Gene ID: 54658
mRNA Refseq: NM_000463
Protein Refseq: NP_000454
MIM: 191740
Chromosome Location: 2q37

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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