Cat. No. :	NTF3-012H
Product Overview :	Human NTF3 (P20783) full-elngth recombinant protein expressed in Escherichia coli.
Description :	Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene. The protein encoded by this gene, NT-3, is a neurotrophic factor in the NGF (Nerve Growth Factor) family of neurotrophins. It is a protein growth factor which has activity on certain neurons of the peripheral and central nervous system; it helps to support the survival and differentiation of existing neurons, and encourages the growth and differentiation of new neurons and synapses. NT-3 was the third neurotrophic factor to be characterized, after nerve growth factor (NGF) and BDNF.
Theoretical MW (kDa) :	13.6
Form :	Lyophilized
Preparation Method :	Escherichia coli expression system
Purity :	μ 98% by SDS-PAGE, μ 98% by HPLC
Endotoxin Level :	< 0.1 ng/ug
Activity :	The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/mL.
Application :	SDS-PAGE
Storage :	Store at -20°C on dry atmosphere.After reconstitution with deionized water, store at -20°C.Aliquot to avoid repeated freezing and thawing.
Unitprot ID :	P20783
Pathways :	Neurotrophin signaling pathway; MAPK signaling pathway

Gene Name :	NTF3 neurotrophin 3 [ Homo sapiens ]
Official Symbol :	NTF3
Synonyms :	NTF3; neurotrophin 3; NT3; HDNF; NGF2; NGF-2; MGC129711; neurotrophin-3; NT-3; OTTHUMP00000239132; OTTHUMP00000239133; neurotrophic factor; nerve growth factor 2; NGF-2; NGF2
Gene ID :	4908
mRNA Refseq :	NM_001102654
Protein Refseq :	NP_001096124
MIM :	162660
Chromosome Location :	12p13
Function :	growth factor activity; nerve growth factor binding; neurotrophin receptor binding

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