"HDAC2" Related Products

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Recombinant Human Histone Deacetylase 2, GST-tagged

Cat. No.: HDAC2-1590H
Product Overview: Full-length recombinant human HDAC2 was expressed by baculovirus in Sf9 insect cells using a C-terminal GST tag.
Description: HDAC2 or Histone deacetylase 2 belongs to the histone deacetylase family that acts via the formation of large multiprotein complexes, and is responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). HDAC2 forms transcriptional repressor complexes by associating with many different proteins and plays an important role in transcriptional regulation, cell cycle progression and developmental events.
Applications: HDAC Assay; Western Blot
Molecular Weight: 92 kDa
Expression System: Sf9 insect cells using baculovirus
Species: Human
Form: Recombinant protein stored in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Purity: >70%
Concentration: 0.1 ug/ul
Specific Activity: 4180 RLU/min/ng
Sequences: Full length
Storage: Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Pathways: Cell cycle; Chronic myeloid leukemia; Direct p53 effectors; Glucocorticoid receptor regulatory network; Hedgehog signaling events mediated by Gli proteins; Hemostasis; Huntington"s disease; Notch signaling pathway; Pathways in cancer; Regulation of Telomerase; Signaling events mediated by HDAC Class I; Signalling by NGF; TNF-alpha/NF-kB Signaling Pathway; p75 NTR receptor-mediated signaling; p75NTR negatively regulates cell cycle via SC1
Gene Name: HDAC2 histone deacetylase 2 [ Homo sapiens ]
Official Symbol: HDAC2
Synonyms: HDAC2; histone deacetylase 2; HD2; RPD3; YAF1; histone deacetylase 2; OTTHUMP00000017046; OTTHUMP00000227077; OTTHUMP00000227078; YY1-associated factor 1; transcriptional regulator homolog RPD3
Gene ID: 3066
mRNA Refseq: NM_001527
Protein Refseq: NP_001518
MIM: 605164
UniProt ID: Q92769
Chromosome Location: 6q21
Function: NAD-dependent histone deacetylase activity (H3-K14 specific); NAD-dependent histone deacetylase activity (H3-K9 specific); NAD-dependent histone deacetylase activity (H4-K16 specific); histone deacetylase activity; histone deacetylase activity (H3-K16 specific); hydrolase activity; transcription factor binding; chromatin binding; enzyme binding; protein deacetylase activity; protein deacetylase activity; sequence-specific DNA binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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