Human Transferrin

Cat. No.: TF-4778H
Product Overview: This product is excellent for use as a growth factor for primary, continuous, and transformed cell lines.
Description: TF is a glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). TF has a molecular weight of around 80 kDa and contains 2 specific high-affinity Fe (III) binding sites.
Source: Human Plasma
Species: Human
Source Testing: The normal human serum/plasma of each donor unit, from which this product was manufactured, has been tested and certified negative for the following by FDA approved testing procedures: HBsAg, Anti-HCV, Anti-HIV-1, Anti-HIV-2, Syphilis, ALT Test and NAT-PCR ( HAV, HIV, HBC, HCV and Parovirus B19). Human blood products should always be treated in accordance with universal handling precautions.
Protein: 97.0% By Lowry.
Purity: > 98% By Cellulose Acetate Electrophoresis.
Iron: 1500 µg/g By Diagnostic Assay.
pH: 7.06 (3% Solution)
Endotoxin: < 0.076 EU/mg By LAL.
Sodium: 0.0-10.0 mg/g By Flame Photometer.
Chloride: 0.0-12.0 mg/g By Coulometric Titrator.
Moisture: 0.87% By Karl Fisher.
Storage: Store at -20°C.
Pathways: EPHB forward signaling; Formation of Platelet plug; HIF-1-alpha transcription factor network; Hemostasis; Iron uptake and transport; Mineral absorption; Platelet Activation; Platelet degranulation; Response to elevated platelet cytosolic Ca2+; Transferrin endocytosis and recycling; Transmembrane transport of small molecules
Gene Name: TF transferrin [ Homo sapiens ]
Official Symbol: TF
Synonyms: TF; transferring; PRO1557; PRO2086; DKFZp781D0156; serotransferrin; siderophilin; OTTHUMP00000197155; beta-1 metal-binding globulin; Serotransferrin; Beta-1 metal-binding globulin; Siderophilin
Gene ID: 7018
mRNA Refseq: NM_001063
Protein Refseq: NP_001054
MIM: 190000
UniProt ID: P02787
Chromosome Location: 3q21
Function: ferric iron binding; metal ion binding; protein binding; ubiquitin protein ligase binding

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