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| Cat. No.: | TF-4778H |
| Product Overview: | This product is excellent for use as a growth factor for primary, continuous, and transformed cell lines. |
| Description: | TF is a glycoprotein that binds iron very tightly but reversibly. Although iron bound to transferrin is less than 0.1% (4 mg) of the total body iron, it is the most important iron pool, with the highest rate of turnover (25 mg/24 h). TF has a molecular weight of around 80 kDa and contains 2 specific high-affinity Fe (III) binding sites. |
| Source: | Human Plasma |
| Species: | Human |
| Source Testing: | The normal human serum/plasma of each donor unit, from which this product was manufactured, has been tested and certified negative for the following by FDA approved testing procedures: HBsAg, Anti-HCV, Anti-HIV-1, Anti-HIV-2, Syphilis, ALT Test and NAT-PCR ( HAV, HIV, HBC, HCV and Parovirus B19). Human blood products should always be treated in accordance with universal handling precautions. |
| Protein: | 97.0% By Lowry. |
| Purity: | > 98% By Cellulose Acetate Electrophoresis. |
| Iron: | 1500 µg/g By Diagnostic Assay. |
| pH: | 7.06 (3% Solution) |
| Endotoxin: | < 0.076 EU/mg By LAL. |
| Sodium: | 0.0-10.0 mg/g By Flame Photometer. |
| Chloride: | 0.0-12.0 mg/g By Coulometric Titrator. |
| Moisture: | 0.87% By Karl Fisher. |
| Storage: | Store at -20°C. |
| Pathways: | EPHB forward signaling; Formation of Platelet plug; HIF-1-alpha transcription factor network; Hemostasis; Iron uptake and transport; Mineral absorption; Platelet Activation; Platelet degranulation; Response to elevated platelet cytosolic Ca2+; Transferrin endocytosis and recycling; Transmembrane transport of small molecules |
| Gene Name: | TF transferrin [ Homo sapiens ] |
| Official Symbol: | TF |
| Synonyms: | TF; transferring; PRO1557; PRO2086; DKFZp781D0156; serotransferrin; siderophilin; OTTHUMP00000197155; beta-1 metal-binding globulin; Serotransferrin; Beta-1 metal-binding globulin; Siderophilin |
| Gene ID: | 7018 |
| mRNA Refseq: | NM_001063 |
| Protein Refseq: | NP_001054 |
| MIM: | 190000 |
| UniProt ID: | P02787 |
| Chromosome Location: | 3q21 |
| Function: | ferric iron binding; metal ion binding; protein binding; ubiquitin protein ligase binding |
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