"SFN" Related Products

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Recombinant Human Stratifin

Cat. No.: SFN-5121H
Product Overview: Recombinant human SFN was expressed in E. coli and purified by using conventional chromatography techniques.
Description: 14-3-3 sigma, also known as Stratifin (SFN), belongs to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.
Concentration: 1 mg/ml
Source: Human
Host: E.coli
Form: Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 50mM NaCl and 10% glycerol.
Purity: > 95% by SDS - PAGE
Sequence: 1-248 amino acids: MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKD
Molecular Mass: 27.7 kDa (248aa), confirmed by MALDI-TOF.
Applications: SDS-PAGE
Storage: Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name: SFN stratifin [ Homo sapiens ]
Official Symbol: SFN
Synonyms: SFN; stratifin; YWHAS; 14-3-3 protein sigma; 14-3-3 sigma; OTTHUMP00000004242; epithelial cell marker protein 1; HME1
Gene ID: 2810
mRNA Refseq: NM_006142
Protein Refseq: NP_006133
MIM: 601290
UniProt ID: P31947
Chromosome Location: 1p36.11
Pathway: Aldosterone-regulated sodium reabsorption; Alpha6-Beta4 Integrin Signaling Pathway; Calcium Regulation in the Cardiac Cell; Cell cycle; Class I PI3K signaling events mediated by Akt; Direct p53 effectors; ErbB1 downstream signaling; FoxO family signaling; Glucocorticoid receptor regulatory network; Insulin-mediated glucose transport; LKB1 signaling events; Myometrial Relaxation and Contraction Pathways; Regulation of Wnt-mediated beta catenin signaling and target gene transcription; Role of Calcineurin-dependent NFAT signaling in lymphocytes; Trk receptor signaling mediated by PI3K and PLC-gamma; a6b1 and a6b4 Integrin signaling; mTOR signaling pathway
Function: protein binding; protein domain specific binding; protein kinase C inhibitor activity

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