Recombinant Human Stratifin
Cat.No. : | SFN-5121H |
Product Overview : | Recombinant human SFN was expressed in E. coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
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Cat. No. : | SFN-5121H |
Description : | 14-3-3 sigma, also known as Stratifin (SFN), belongs to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. |
Concentration : | 1 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 50mM NaCl and 10% glycerol. |
Purity : | > 95% by SDS - PAGE |
Sequence : | 1-248 amino acids: MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKD |
Molecular Mass : | 27.7 kDa (248aa), confirmed by MALDI-TOF. |
Applications : | SDS-PAGE |
Storage : | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | SFN stratifin [ Homo sapiens ] |
Official Symbol : | SFN |
Synonyms : | SFN; stratifin; YWHAS; 14-3-3 protein sigma; 14-3-3 sigma; OTTHUMP00000004242; epithelial cell marker protein 1; HME1 |
Gene ID : | 2810 |
mRNA Refseq : | NM_006142 |
Protein Refseq : | NP_006133 |
MIM : | 601290 |
UniProt ID : | P31947 |
Chromosome Location : | 1p36.11 |
Pathway : | Aldosterone-regulated sodium reabsorption; Alpha6-Beta4 Integrin Signaling Pathway; Calcium Regulation in the Cardiac Cell; Cell cycle; Class I PI3K signaling events mediated by Akt; Direct p53 effectors; ErbB1 downstream signaling; FoxO family signaling; Glucocorticoid receptor regulatory network; Insulin-mediated glucose transport; LKB1 signaling events; Myometrial Relaxation and Contraction Pathways; Regulation of Wnt-mediated beta catenin signaling and target gene transcription; Role of Calcineurin-dependent NFAT signaling in lymphocytes; Trk receptor signaling mediated by PI3K and PLC-gamma; a6b1 and a6b4 Integrin signaling; mTOR signaling pathway |
Function : | protein binding; protein domain specific binding; protein kinase C inhibitor activity |
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◆ Lysates | ||
SFN-1912HCL | Recombinant Human SFN 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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