Recombinant Human Hypoxia Inducible Factor 1, Alpha Subunit, His-tagged
Cat.No. : | HIF1A-5020H |
Product Overview : | Recombinant human Hif-1 alpha (1-85) protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques. |
- Specification
- Gene Information
- Related Products
Cat. No. : | HIF1A-5020H |
Description : | Hypoxia-inducible factor-1 (HIF-1), identified as one of the transcription factors, has been found to play an essential role in oxygen homeostasis. HIF-1 is a heterodimer composed of HIF-1 beta subunit and one of three subunits (Hif-1 alpha, Hif-2 alpha or Hif-3 alpha). The activation of Hif-1 alpha is closely associated with a variety of tumors and oncogenic pathways. Hif-1 alpha consists of DNA binding domain(DBD domain), dimerization domain and C-terminal regulatory domains, including two transactivation domains(TAD), an oxygen-dependent degradation(ODD) domain, and inhibitory domains. |
Concentration : | 0.25 mg/ml |
Source : | Human |
Host : | E.coli |
Form : | Supplied as a liquid in 20mM Tris buffer, pH 8.0, containing 20% glycerol, 1mM DTT, 0.2M NaCl and 1mM EDTA. |
Purity : | > 80% by SDS - PAGE |
Sequence : | 1-85 amino acids: MGSSHHHHHH SSGLVPRGSH MEGAGGANDK KKISSERRKE KSRDAARSRR SKESEVFYEL AHQLPLPHNV SSHLDKASVM RLTISYLRVR KLLDAGDLDI EDDMK |
Molecular Mass : | 27.7 kDa (248aa), confirmed by MALDI-TOF. |
Applications : | SDS-PAGE |
Storage : | Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Gene Name : | HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [ Homo sapiens ] |
Official Symbol : | HIF1A |
Synonyms : | HIF1A; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); HIF1; MOP1; PASD8; bHLHe78; HIF-1alpha; HIF1-ALPHA; Hypoxia-inducible factor 1 alpha; HIF1 alpha; ARNT-interacting protein; Member of PAS protein 1; Basic-helix-loop-helix-PAS protein; ARNT interacting protein; hypoxia-inducible factor 1 alpha isoform I.3; member of PAS superfamily 1; hypoxia-inducible factor 1, alpha subunit |
Gene ID : | 3091 |
mRNA Refseq : | NM_001530 |
Protein Refseq : | NP_001521 |
MIM : | 603348 |
UniProt ID : | Q16665 |
Chromosome Location : | 14q21-q24 |
Pathway : | Pathways in cancer; Renal cell carcinoma; mTOR signaling pathway |
Function : | Hp90 protein binding; RNA polymerase II transcription factor activity, enhancer binding; histone acetyltransferase binding; protein heterodimerization activity; sequence-specific DNA binding; signal transducer activity; transcription factor binding |
Products Types
◆ Recombinant Protein | ||
HIF1A-22H | Recombinant Human HIF1A Protein, T7-His-TEV-tagged | +Inquiry |
HIF1A-0486H | Recombinant Human HIF1A Protein (E2-N826), Tag Free | +Inquiry |
HIF1A-0487H | Recombinant Human HIF1A Protein (E2-N826), His/Strep tagged | +Inquiry |
HIF1A-2240H | Recombinant Human HIF1A Protein, His-tagged | +Inquiry |
HIF1A-3111H | Recombinant Human HIF1A Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
HIF1A-787HCL | Recombinant Human HIF1A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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