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Recombinant Human Hypoxia Inducible Factor 1, Alpha Subunit Inhibitor

Cat.No. : HIF1AN-5022H
Product Overview : Recombinant human HIF1AN protein was expressed in E. coli and purified by using conventional chromatography techniques.
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Cat. No. : HIF1AN-5022H
Description : Hypoxia-inducible factor 1, alpha subunit inhibitor (HIF1AN), a member of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, is a protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1alpha C-terminal transactivation domain. In normoxia, the HIF1AN-mediated hydroxylation of the HIF1alpha transactivation domain results in blockage of the HIF1alpha-p300/CBP interaction and represses transcriptional activity of HIF1alpha-targeted genes.
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0.
Purity : > 90% by SDS - PAGE
Sequence : 1-349 amino acids: MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKR
Molecular Mass : 40.2 kDa (349 aa), confirmed by MALDI-TOF.
Applications : SDS-PAGE
Storage : Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Gene Name : HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor [ Homo sapiens ]
Official Symbol : HIF1AN
Synonyms : HIF1AN; DKFZp762F1811; FIH1; FLJ20615; FLJ22027; hypoxia inducible factor 1, alpha subunit inhibitor; OTTHUMP00000020284; factor inhibiting HIF1; peptide-aspartate beta-dioxygenase; DKFZp762F1811; EC 1.14.11.16; FIH-1; Factor inhibiting HIF-1; Hypoxia-inducible factor asparagine hydroxylase; factor inhibiting HIF1; hypoxia-inducible factor 1, alpha subunit inhibitor
Gene ID : 55662
mRNA Refseq : NM_017902
Protein Refseq : NP_060372
MIM : 606615
UniProt ID : Q9NWT6
Chromosome Location : 10q24
Pathway : HIF-2-alpha transcription factor network; Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Function : iron ion binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two; atoms of oxygen; peptide-aspartate beta-dioxygenase activity; protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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