Recombinant Human CD4 Molecule (411-459)

Cat. No.: CD4-104H
Product Overview: Recombinant Human CD4produced inEscherichia Coli encoding amino acids 411-459.
Description: CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. Antibody to CD4 recognizes T-helper cells required for recognition of class II antigens. It reacts with ~60% of peripheral blood E rosette-positive (E+) cells while showing negligible reactivity with E- cells, monocytes, granulocytes, EBV-transformed B cell lines, and mouse splenocytes.
Source: Escherichia Coli.
Physical Appearance: Sterile filtered liquid.
Formulation: Recombinant Human CD4 protein at 100µg/ml in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Application and Suggested Dilutions: •ELISA •Inhibition Assays •Western Blotting
Characterization: On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48kDa.
Storage: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles.
Gene Name: CD4 molecule [ Homo sapiens ]
Synonyms: Gp55; HLA-2; L3 / T4; Ly-4; T cell antigen T4/LEU3; T4; sCD4; CD4mut; CD4; CD4 antigen; CD4 antigen (p55); CD4 molecule; CD4 receptor; T-cell surface antigen T4/Leu-3; CD4 molecule; 12pter-p12
Gene ID: 920
mRNA Refseq: NM_000616
Protein Refseq: NP_000607
MIM: 186940
UniProt ID: P01730
Chromosome Location: 12pter-p12
Pathway: Primary immunodeficiency; Antigen processing and presentation; Hematopoietic cell lineage; Cell adhesion molecules (CAMs); T cell receptor signaling pathway
Function: MHC class II protein binding; coreceptor activity; extracellular matrix structural constituent; glycoprotein binding; protein kinase binding; zinc ion binding; protein homodimerization activity; transmembrane receptor activity

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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