| Description : |
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages |
| Source : |
HEK293 |
| Species : |
Macaca Fascicularis |
| Tag : |
His |
| Form : |
Lyophilized powder |
| Molecular Mass : |
41.5 kDa |
| Protein length : |
373 |
| AA Sequence : |
KKVVLGKKGDTVELTCNASQKKNTQ FHWKNSNQIKILGIQGSFLTKGPSK LSDRADSRKSLWDQGCFSMIIKNLK IEDSDTYICEVENKKEEVELLVFGL TANSDTHLLEGQSLTLTLESPPGSS PSVKCRSPGGKNIQGGRTLSVPQLE RQDSGTWTCTVSQDQKTVEFKIDIV VLAFQKASSTVYKKEGEQVEFSFPP AFTLEKLTGSGELWWQAERASSSKS WITFDLKNKEVSVKRVTQDPKLQMG KKLPLHLTLPQALPQYAGSGNLTLA LEAKTGKLHQEVNLVVMRATQFQEN LTCEVWGPTSPKLTLSLKLENKGTT VSKQAKAVWVLNPEAGMWQCLLSDS GQVLLESNIKVVPTWHHHHHHHH |
| Endotoxin : |
＜1EU/ug by LAL |
| Purity : |
＞95% by SDS-PAGE |
| Applications : |
ELISA |
| Storage : |
Store it under sterile conditions at -20 to -80 ºC. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : |
Lyophilized from sterile PBS, pH 7.4. 5% trehalose and mannitol are added as protectants before lyophilization. |
