Recombinant Human NFE2L2, His-tagged

• Cat.No.: NFE2L2-8469H
• Product Overview: Recombinant Human NFE2L2, fused with His tag, was expressed in E. coli.

Specification

• Description: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters. many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: E. coli
• Species: Human
• Tag: His
• Form: 20 mM Tris-Cl, pH 7.9, 20% Glycerol. 100 mM KCl. 1 mM DTT and 0.2 mM EDTA
• Molecular Mass: 69.9 kDa
• Endotoxin: Less than 1.0 EU/μg by LAL method
• Purity: >95% as determined by SDS-PAGE
• Storage: -80 °C
• Shipping: Dry Ice

Gene Information

• Gene Name: NFE2L2 nuclear factor (erythroid-derived 2)-like 2 [ Homo sapiens ]
• Official Symbol: NFE2L2
• Synonyms: NFE2L2; nuclear factor (erythroid-derived 2)-like 2; nuclear factor erythroid 2-related factor 2; NF E2 related factor 2; NRF2; HEBP1; NFE2-related factor 2; NF-E2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid derived 2, like 2
• Gene ID: 4780
• mRNA Refseq: NM_001145412
• Protein Refseq: NP_001138884
• MIM: 600492
• UniProt ID: Q16236
• Chromosome Location: 2q31
• Pathway: Keap1-Nrf2 Pathway, organism-specific biosystem; Protein processing in endoplasmic reticulum, organism-specific biosystem; Protein processing in endoplasmic reticulum, conserved biosystem
• Function: DNA binding; protein dimerization activity; protein domain specific binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity