Recombinant Human DCP2, His-tagged DCP2-11861H

Recombinant Human DCP2, His-tagged

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Cat.No. :	DCP2-11861H
Product Overview :	Recombinant Human DCP2 protein, fused to His-tag, was expressed in E.coli and purified by Ni-sepharose.
Description :	The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5 end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Source :	E.coli
Species :	Human
Tag :	His
Protein length :	1-385a.a.
Storage :	The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer :	1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 300mM Imidazole and 0.7% Sarcosyl, 15%glycerol.

Gene Name :	DCP2 DCP2 decapping enzyme homolog (S. cerevisiae) [ Homo sapiens ]
Official Symbol :	DCP2
Synonyms :	DCP2; DCP2 decapping enzyme homolog (S. cerevisiae); mRNA-decapping enzyme 2; nudix (nucleoside diphosphate linked moiety X) type motif 20; NUDT20; hDpc; nudix (nucleoside diphosphate linked moiety X)-type motif 20; FLJ33245;
Gene ID :	167227
mRNA Refseq :	NM_001242377
Protein Refseq :	NP_001229306
MIM :	609844
UniProt ID :	Q8IU60
Chromosome Location :	5q22
Pathway :	Activation of Genes by ATF4, organism-specific biosystem; Deadenylation-dependent mRNA decay, organism-specific biosystem; Decapping complex, organism-specific biosystem; Decapping complex, conserved biosystem; Destabilization of mRNA by Butyrate Response Factor 1 (BRF1), organism-specific biosystem; Destabilization of mRNA by KSRP, organism-specific biosystem; Destabilization of mRNA by Tristetraprolin (TTP), organism-specific biosystem;
Function :	RNA binding; exoribonuclease activity, producing 5-phosphomonoesters; hydrolase activity; manganese ion binding; metal ion binding; protein binding;