"DHFR" Related Products

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Recombinant Human DHFR, GST-tagged

Cat.No.: DHFR-11966H
Product Overview: Recombinant Human DHFR protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Description: Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
Source: E.coli
Species: Human
Tag: GST
Protein length: 1-187a.a.
Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name: DHFR dihydrofolate reductase [ Homo sapiens ]
Official Symbol: DHFR
Synonyms: DHFR; dihydrofolate reductase; DYR; DHFRP1;
Gene ID: 1719
mRNA Refseq: NM_000791
Protein Refseq: NP_000782
MIM: 126060
UniProt ID: P00374
Chromosome Location: 5q11.2-q13.2
Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; E2F mediated regulation of DNA replication, organism-specific biosystem; E2F transcription factor network, organism-specific biosystem; Fluoropyrimidine Activity, organism-specific biosystem; Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem;

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