Recombinant Human HGS, GST-tagged

• Cat.No.: HGS-13762H
• Product Overview: Recombinant Human HGS protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Description: The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.
• Source: E.coli
• Species: Human
• Tag: GST
• Protein length: 186-387a.a.
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: HGS hepatocyte growth factor-regulated tyrosine kinase substrate [ Homo sapiens ]
• Official Symbol: HGS
• Synonyms: HGS; hepatocyte growth factor-regulated tyrosine kinase substrate; Hrs; Vps27; ZFYVE8; protein pp110; human growth factor-regulated tyrosine kinase substrate; HRS; FLJ11421; FLJ39878
• Gene ID: 9146
• mRNA Refseq: NM_004712
• Protein Refseq: NP_004703
• MIM: 604375
• UniProt ID: O14964
• Chromosome Location: 17q25
• Pathway: CXCR4-mediated signaling events, organism-specific biosystem; Disease, organism-specific biosystem; EGFR downregulation, organism-specific biosystem; ESCRT-0 complex, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Endosomal Sorting Complex Required For Transport (ESCRT), organism-specific biosystem
• Function: metal ion binding; protein binding; protein domain specific binding

Reviews

05/13/2019

Minimal background noise in our assays was indicative of the product's superior quality.

01/24/2018

Compatibility with a range of assays expanded our research possibilities significantly.

12/19/2016

Our research benefited greatly from the product's ability to induce specific cellular responses, enriching our findings.

Q&As

How does HGS contribute to the regulation of cell signaling and receptor downregulation in the endocytic pathway?

HGS contributes to the regulation of cell signaling by promoting the downregulation of activated receptors in the endocytic pathway.

What diseases or conditions are associated with dysregulation or abnormal expression of HGS?

Dysregulation or abnormal expression of HGS is associated with conditions such as cancer and neurodegenerative disorders.

How does HGS participate in the endocytic pathway, particularly in the degradation of receptor tyrosine kinases (RTKs)?

HGS participates in the endocytic pathway by facilitating the degradation of receptor tyrosine kinases (RTKs) through the ESCRT complex.

What is the primary function of Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) in cellular processes and intracellular trafficking?

Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) functions in cellular processes, primarily playing a role in intracellular trafficking.

In which cellular compartments is HGS predominantly localized?

HGS is predominantly localized in endosomes and lysosomes, key compartments for the endocytic pathway.

Are there specific interactions or binding partners of HGS that influence its role in intracellular trafficking?

Specific interactions or binding partners of HGS include ESCRT components, influencing its role in receptor downregulation and intracellular trafficking.

Are there therapeutic implications or potential targets related to HGS in diseases involving intracellular trafficking and signaling?

There are potential therapeutic implications related to HGS in diseases involving intracellular trafficking and signaling, making it a target for drug development.