Description : |
CD160 antigen, also known as Natural killer cell receptor BY55 and CD160, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and small intestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD160+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness. |
Source : |
Human Cells |
Species : |
Cynomolgus |
Tag : |
His |
Predicted N Terminal : |
Gly 25 |
Form : |
Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements. |
Molecular Mass : |
The recombinant cynomolgus CD160 comprises 145 amino acids and has a calculated molecular mass of 16.3 KDa. The apparent molecular mass of it is approximately 25 and 22 KDa respectively in SDS-PAGE. |
Endotoxin : |
< 1.0 eu per ug of the protein as determined by the lal |
Purity : |
(70+22.5)% as determined by SDS-PAGE |
Stability : |
Samples are stable for up to twelve months from date of receipt at -70℃ |
Storage : |
Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : |
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information. |