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Recombinant Rhesus monkey IL13

Cat.No.: IL13-542R
Product Overview: Recombinant Rhesus monkey IL13 produced in E. coli is approximately 12.6 kDa, a single non-glycosylated polypeptide chain containing 114 amino acids.
Description: Interleukin-13 (IL-13) is expressed by the IL13 gene and secreted by many cell types, especially T helper type 2 (Th2) cells. The high solution from of IL-13 reported to be a monomer with two internal disulfide bonds that contribute to a bundled four α-helix configuration. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Mature rhesus IL13 shares 94%, 58%, and 60% amino acid sequence identity with human, mouse, and rat IL13, respectively.
Source: E. coli
Species: Rhesus monkey
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 3% trehalose.
Bio-activity: Fully biologically active when compared to standard. The ED50 determined by a cell proliferation assay using human TF-1 cells is less than 5 ng/ml, corresponding to a specific activity of >2.0 × 10^6 IU/mg.
Molecular Mass: 12.6 kDa
AA Sequence: SPSPVPRSTA LKELIEELVN ITQNQKAPLC NGSMVWSINL TAGVYCAALE SLINVSGCSA IEKTQRMLNG FCPHKVSAGQ FSSLRVRDTK IEVAQFVKDL LVHLKKLFRE GRFN
Endotoxin: Less than 1 EU/μg of rRhIL-13 as determined by LAL method.
Purity: >98% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apport
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportion
Gene Name: IL13 interleukin 13 [ Macaca mulatta (Rhesus monkey) ]
Official Symbol: IL13
Synonyms: IL13;interleukin-13;IL-13
Gene ID: 574325
mRNA Refseq: NM_001032929.1
Protein Refseq: NP_001028101.1
UniProt ID: Q864V6
Chromosome Location: chromosome: 6
Pathway: Asthma;Cytokine-cytokine receptor interaction

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