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Recombinant Mouse Ccl11

Cat.No.: Ccl11-620M
Product Overview: Recombinant Mouse Ccl11 produced in E. coli is approximately 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.
Description: Eotaxin also called CCL11 is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions.
Source: E. coli
Species: Mouse
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Bio-activity: Fully biologically active when compared to standard. The ED 50 determined by a chemotaxis bioassay using murine CCR3 transfected BaF3 murine proB cells is less than 5 ng/ml, corresponding to a specific activity of >2.0 × 10^5 IU/mg.
Molecular Mass: 8.4 kDa
AA Sequence: HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP
Endotoxin: Less than 1 EU/μg of rMuMCP-5/CCL12 as determined by LAL method.
Purity: >95% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at< -20 centigrade. further dilutions should be made in appropriate buffered solutions.>
Gene Name: Ccl11 chemokine (C-C motif) ligand 11 [ Mus musculus ]
Official Symbol: Ccl11
Synonyms: CCL11; chemokine (C-C motif) ligand 11; eotaxin; C-C motif chemokine 11; small inducible cytokine A11; small-inducible cytokine A11; eosinophil chemotactic protein; small chemokine (C-C motif) ligand 11; Scya11;
Gene ID: 20292
mRNA Refseq: NM_011330
Protein Refseq: NP_035460
Pathway: Asthma, organism-specific biosystem; Asthma, conserved biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function: chemokine activity; cytokine activity;

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