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Recombinant Rat Ccl22

Cat.No.: Ccl22-637R
Product Overview: Recombinant Rat Ccl22 produced in E. coli is approximately 7.9 kDa, a single, non-glycosylated polypeptide chain containing 68 amino acids.
Description: Macrophage-Derived Chemokine/CCL22 (MDC) is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity.
Source: E. coli
Species: Rat
Form: Lyophilized from a 0.2 μm filtered concentrated solution in 2 × PBS, pH7.4.
Bio-activity: Fully biologically active when compared to standard. The biologically active determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration range of 10-100 ng/ml.
Molecular Mass: 7.9 kDa
AA Sequence: GPYGANVEDS ICCQDYIRHP LPPRFVKEFY WTSKSCRKPG VVLITIKNRD ICADPRMLWV KKILHKLA
Endotoxin: Less than 1 EU/μg of rRtMDC/CCL22 as determined by LAL method.
Purity: >96% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: Ccl22 chemokine (C-C motif) ligand 22 [ Rattus norvegicus ]
Official Symbol: Ccl22
Synonyms: CCL22; chemokine (C-C motif) ligand 22; C-C motif chemokine 22; small inducible cytokine A22; small inducible cytokine subfamily A (Cys-Cys) member 22; small inducible cytokine subfamily A (Cys-Cys), member 22; Mdc; Scya22; MGC108943;
Gene ID: 117551
mRNA Refseq: NM_057203
Protein Refseq: NP_476551
Pathway: Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem;
Function: molecular_function;

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