Recombinant Human PLK4, GST-tagged
Cat.No. : | PLK4-1789H |
Product Overview : | Recombinant Human PLK4 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose. |
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Source : | E.coli |
Species : | Human |
Tag : | GST |
Protein length : | 1-263aa |
Storage : | The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles. |
Storage Buffer : | 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol. |
Gene Name : | PLK4 polo-like kinase 4 [ Homo sapiens ] |
Official Symbol : | PLK4 |
Synonyms : | PLK4; polo-like kinase 4; polo like kinase 4 (Drosophila) , serine/threonine kinase 18 , STK18; serine/threonine-protein kinase PLK4; Sak; PLK-4; Snk akin kinase; serine/threonine kinase 18; serine/threonine-protein kinase 18; serine/threonine protein kinase SAK; serine/threonine-protein kinase Sak; SAK; STK18; |
Gene ID : | 10733 |
mRNA Refseq : | NM_001190799 |
Protein Refseq : | NP_001177728 |
MIM : | 605031 |
UniProt ID : | O00444 |
Chromosome Location : | 4q27-q28 |
Pathway : | Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; Centrosome maturation, organism-specific biosystem; G2/M Transition, organism-specific biosystem; Loss of Nlp from mitotic centrosomes, organism-specific biosystem; Loss of proteins required for interphase microtubule organization??from the centrosome, organism-specific biosystem; Mitotic G2-G2/M phases, organism-specific biosystem; |
Function : | ATP binding; nucleotide binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity; |
Products Types
◆ Recombinant Protein | ||
PLK4-1166H | Recombinant Human PLK4 Protein (G581-G808), Tag Free | +Inquiry |
PLK4-39H | Recombinant Active Human PLK4 (G95L) Mutant Protein, GST-tagged | +Inquiry |
PLK4-6854M | Recombinant Mouse PLK4 Protein, His (Fc)-Avi-tagged | +Inquiry |
PLK4-01H | Recombinant Human PLK4 (G95L) Protein, GST-tagged | +Inquiry |
PLK4-1167H | Recombinant Human PLK4 Protein (G581-G808), His tagged | +Inquiry |
◆ Lysates | ||
PLK4-3102HCL | Recombinant Human PLK4 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionThere is an interaction between PLK4 protein and other proteins. For example, it interacts with certain proteins on spindle fibers to regulate chromosome segregation, and with other proteins in signal transduction pathways to regulate cell proliferation and differentiation.
PLK4 protein is mainly responsible for regulating the process of chromosome segregation and cytoplasmic division in cell division. It is associated with the assembly and function of spindle fibers, affecting the accuracy of chromosome segregation and cell division.
Certain biomolecules can be used as molecular markers of PLK4 protein, such as mRNA or protein of PLK4 protein detected in biological samples such as blood and urine. These markers can be used for early diagnosis of disease, prognostic judgment, or monitoring of treatment efficacy.
Therapeutics targeting the PLK4 protein are still in the early stages of research. A number of small molecule inhibitors and antibody drugs have been developed and initially evaluated in laboratories and clinical trials. However, further research and clinical validation of these treatments are needed to determine their safety and efficacy.
Therapeutic strategies for PLK4 protein include inhibition of its activity, regulation of its expression, and gene therapy. For example, the development of small molecule inhibitors or antibody drugs against the PLK4 protein to inhibit its aberrant activity in tumors, or the regulation of PLK4 protein expression through gene knockout or overexpression techniques.
Studies have shown that the abnormal expression of PLK4 protein is associated with the occurrence of a variety of tumors, including but not limited to brain cancer, lung cancer, breast cancer, pancreatic cancer, etc. It may be related to aspects such as proliferation, metastasis, and drug resistance of tumor cells.
Customer Reviews (3)
Write a reviewWith PLK4, the sensitivity of the experiment was significantly improved.
Strong anti-pollution ability, not easy to pollute, to ensure the accuracy of the experiment.
The method is very simple, and it is easy to obtain accurate experimental results.
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