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Recombinant Mouse IL21, MIgG2a Fc-tagged

Cat.No.: IL21-021M
Product Overview: The extracellular domain of mouse IL-21 (NP_068554.1)(His18-Ser146) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell
Description: This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. Theencoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation,proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells andcytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus,psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoformshave been observed for this gene
Source: CHO cells
Species: Mouse
Tag: MIgG2a Fc-tagged
Form: Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity: Measured in a cell proliferation assay using N1186 human T cells.
Molecular Mass: 43KDa (monomer)
AA Sequence: His18-Ser146
Endotoxin: <0.06 eu/μg as determined by lal test.>
Purity: >98%, by SDS-PAGE under reducing conditions.
Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
Warning: Avoid freeze/thaw cycles.
Gene Name: Il21 interleukin 21 [ Mus musculus ]
Official Symbol: IL21
Synonyms: IL21; interleukin 21; interleukin-21; IL-21;
Gene ID: 60505
mRNA Refseq: NM_021782
Protein Refseq: NP_068554
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function: cytokine activity; cytokine receptor binding; interleukin-2 receptor binding;

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