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Recombinant Human TRIM21 293 Cell Lysate

Cat.No. : TRIM21-791HCL
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  • Gene Information
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Description : Antigen standard for tripartite motif-containing 21 (TRIM21) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : TRIM21 tripartite motif containing 21 [ Homo sapiens ]
Official Symbol : TRIM21
Synonyms : TRIM21; tripartite motif containing 21; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS A/Ro) , SSA1, tripartite motif containing 21; E3 ubiquitin-protein ligase TRIM21; RNF81; RO52; SS-A; ro(SS-A); 52 kDa Ro protein; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro); SSA; SSA1;
Gene ID : 6737
mRNA Refseq : NM_003141
Protein Refseq : NP_003132
MIM : 109092
UniProt ID : P19474
Chromosome Location : 11p15.5-p15.3
Pathway : Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing & presentation, organism-specific biosystem; Immune System, organism-specific biosystem; Systemic lupus erythematosus, organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any specific viral infections that TRIM21 is particularly effective against? 10/31/2022

TRIM21 has demonstrated efficacy against a broad range of viruses, including but not limited to influenza, herpes simplex virus, and adenovirus.

How does TRIM21 function in the immune system? 11/14/2020

TRIM21 acts as an intracellular antibody receptor, binding to antibodies that have attached to viruses inside the cell. This binding triggers a process that leads to the destruction of the virus.

What are the potential clinical applications of TRIM21? 02/28/2019

TRIM21 has promising applications in various clinical settings, particularly in the development of therapies for viral infections and autoimmune diseases.

How does TRIM21 contribute to the treatment of autoimmune diseases? 05/15/2017

TRIM21's role in regulating immune responses makes it a potential target for therapies aimed at modulating the immune system in autoimmune diseases.

Can TRIM21 be used in antiviral therapies? 06/05/2016

Yes, TRIM21's ability to target and degrade antibody-bound viruses makes it a potential candidate for antiviral therapies.

Customer Reviews (3)

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Reviews
08/13/2022

    They can provide fast and efficient delivery services, minimizing any potential delays and allowing researchers to proceed with their studies in a timely manner.

    12/30/2020

      The manufacturer can provide researchers with a high-quality, purified form of TRIM21 protein, ensuring its integrity and functionality for experimental use.

      10/11/2017

        A manufacturer with a responsive and dedicated customer support team can address any concerns or queries that researchers may have.

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