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Recombinant Human CCR2 293 Cell Lysate

Cat.No. : CCR2-7696HCL
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  • Gene Information
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Description : Antigen standard for chemokine (C-C motif) receptor 2 (CCR2), transcript variant A is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection.
Source : HEK 293 cells
Species : Human
Components : This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol).
Size : 0.1 mg
Storage Instruction : Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment.
Applications : ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane.
Gene Name : CCR2 chemokine (C-C motif) receptor 2 [ Homo sapiens ]
Official Symbol : CCR2
Synonyms : CCR2; chemokine (C-C motif) receptor 2; CMKBR2; CC CKR 2; CD192; CKR2; FLJ78302; MCP 1 R; CCR2A; CCR2B; CKR2A; CKR2B; MCP-1-R; CC-CKR-2;
Gene ID : 1231
MIM : 601267
UniProt ID : P41597
Chromosome Location : 3p21
Pathway : Beta defensins, organism-specific biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Defensins, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Which drugs interact with CCR2 proteins? 12/30/2019

Antagonists of multiple CCR2 proteins have been developed to inhibit the binding of CCR2 to its ligand CCL2, thereby regulating the inflammatory response and migration of immune cells.

Does CCR2 protein research have implications for new drug development? 12/16/2019

CCR2 protein plays an important role in the field of immune inflammation, and studying the function and regulatory mechanism of CCR2 protein will help the development of new drugs, for example, antagonists targeting CCR2 protein may be applied to the treatment of inflammatory diseases.

What is the role of CCR2 protein in infectious diseases? 12/06/2019

The CCR2 protein plays an important role in the migration and activation of macrophages and may therefore be involved in the initiation and progression of infectious diseases.

Has a diagnostic method been developed to interact with the CCR2 protein? 06/08/2019

There are no specific diagnostic methods for the CCR2 protein, but the CCR2 protein could be a potential candidate for inflammatory markers.

What is the mechanism of action of CCR2 protein in inflammatory response? 05/18/2019

By binding to its ligand CCL2, CCR2 protein regulates the release of inflammatory mediators, the migration of immune cells, and the occurrence of inflammatory responses.

What are the potential applications of CCR2 protein in immune vaccine design? 05/05/2019

CCR2 protein plays an important role in the activation and migration of immune cells, so it can be used in immune vaccine design to promote immune cell infiltration and antigen presentation.

Customer Reviews (3)

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Reviews
06/03/2022

    This reproducibility of CCR2 was very good, showing good production process and quality control.

    12/10/2020

      I appreciate the attention paid to product quality by the producers of CCR2, and their product is very stable, which makes our experiments smoother.

      10/22/2019

        The bands of CCR2 in Western blot were regular in shape and showed good quality.

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