Cat.No.: | CNTF-376HCL |
Description: | The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of ZFP91 and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. |
Species: | Human |
Size: | 100 ul |
Storage Buffer: | 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue) |
Applications: | Western Blot; |
Gene Name: | CNTF ciliary neurotrophic factor [ Homo sapiens ] |
Official Symbol: | CNTF |
Synonyms: | CNTF; ciliary neurotrophic factor; HCNTF; |
Gene ID: | 1270 |
mRNA Refseq: | NM_000614 |
Protein Refseq: | NP_000605 |
MIM: | 118945 |
UniProt ID: | P26441 |
Chromosome Location: | 11q12 |
Pathway: | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Delta-Notch Signaling Pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; |
Function: | ciliary neurotrophic factor receptor binding; cytokine activity; growth factor activity; interleukin-6 receptor binding; |
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