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Recombinant Mouse Galc, Myc-His-tagged

Cat.No.: Galc-200M
Product Overview: Recombinant Mouse Galactocerebrosidase/ GALC Protein,C-Myc & His Tag (Mouse Galactocerebrosidase /GALC ) Tyr 43 - Arg 684 (Accession # P54818) was produced in human 293 cells (HEK293).
Description: Galactocerebrosidase (GALC) is also known as GALCERase, Galactocerebroside beta-galactosidase, Galactosylceramidase and Galactosylceramide beta-galactosidase, which belongs to the glycosyl hydrolase 59 family. Galactocerebrosidase / GALC hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. GALC with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. Defects in Galc are the cause of the "twitcher" phenotype.
Source: HEK293
Species: Mouse
Tag: Myc-His
Form: Lyophilized from 0.22 μm filtered solution in 50 mM MES, pH 6.5 with 100 mM NaCl. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Endotoxin: Less than 1.0 EU per μg of the Mouse Galactocerebrosidase /GALC by the LAL method.
Purity: >90% as determined by SDS-PAGE.
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Reconstitution: See Certificate of Analysis for reconstitution instructions and specific concentrations.
Gene Name: Galc galactosylceramidase [ Mus musculus ]
Official Symbol: Galc
Synonyms: GALC; galactosylceramidase; galactocerebrosidase; GALCERase; galactocerebroside beta-galactosidase; galactosylceramide beta-galactosidase; twi; Gacy; AW212969; AW413532; twitcher; 2310068B06Rik; A930008M05Rik;
Gene ID: 14420
mRNA Refseq: NM_008079
Protein Refseq: NP_032105
Pathway: Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Metabolic pathways, organism-specific biosystem; Sphingolipid metabolism, organism-specific biosystem; Sphingolipid metabolism, conserved biosystem;
Function: catalytic activity; cation binding; galactosylceramidase activity; hydrolase activity; hydrolase activity, acting on glycosyl bonds;

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