"NLK" Related Products


Recombinant Human NLK, GST-tagged

Cat.No.: NLK-1066H
Product Overview: Recombinant full-length human NLK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Description: NLK (also known as nemo-like kinase) is a member of the serine/threonine protein kinase that is encoded by the NLK gene. NLK plays a role in cell fate determination and is required for the differentiation of bone marrow stromal cells. NLK also suppresses a wide range of transcription factors such as CREB by phosphorylation of the co-activator CREBBP. NLK expression increases the number of apoptotic cells but does not induce obvious cell cycle arrest. NLK suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex.
Source: Sf9 insect cells
Species: Human
Tag: GST
Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Bio-activity: 2.4 nmol/min/mg
Molecular Mass: ~84 kDa
Protein length: Full Length
Purity: >85%
Applications: Western Blot
Stability: 1 yr at -70oC from date of shipment.
Storage: Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Concentration: 0.1 ug/ul
Gene Name: NLK nemo-like kinase [ Homo sapiens ]
Official Symbol: NLK
Synonyms: NLK; nemo-like kinase; serine/threonine-protein kinase NLK; NP_057315.3; EC
Gene ID: 51701
mRNA Refseq: NM_016231
Protein Refseq: NP_057315
MIM: 609476
UniProt ID: Q9UBE8
Chromosome Location: 17q11.2
Pathway: Adherens junction; C-MYB transcription factor network; IL-6 Signaling Pathway; MAPK signaling pathway
Function: ATP binding; MAP kinase activity; SH2 domain binding; magnesium ion binding

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