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Recombinant Human FCER1A, His-tagged, Biotinylated

Cat.No.: FCER1A-193H
Product Overview: Human FCER1A Protein, Biotinylated (Biotinylated rh FCER1A) Val 26 - Gln 205 (Accession # NP_001992), was labeled with biotin based on rh FCER1A Protein, which was produced in human 293 cells (HEK293).
Description: High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) is also known as Fc-epsilon RI-alpha (FcERI), IgE Fc receptor subunit alpha, FCE1A. FCER1A contains two Ig-like (immunoglobulin-like) domains. FCER1A binds to the Fc region of immunoglobulins epsilon and is a high affinity receptor. FCER1A is responsible for initiating the allergic response, which binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines. FCER1A plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma.
Source: HEK293
Species: Human
Tag: His
Predicted N Terminal: Val 26
Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose are added as protectants before lyophilization.
Molecular Mass: Biotinylated rh FCER1A is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 21.9 kDa. The predicted N-terminus is Val 26. DTT-reduced Protein migrates as 40-60 kDa in SDS-PAGE due to glycosylation.The primary amine of Biotinyla
Endotoxin: Less than 1.0 EU per μg of the Biotinylated rh FCER1A by the LAL method.
Purity: >95% as determined by SDS-PAGE.
Applications: Biotin Labeled Protein
Storage: Avoid repeated freeze-thaw cycles.No activity loss was observed after storage at:In lyophilized state for 1 year (4oC); After reconstitution under sterile conditions for 3 months (-70oC).
Gene Name: FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide [ Homo sapiens ]
Official Symbol: FCER1A
Synonyms: FCER1A; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; FCE1A; high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide; FcERI;
Gene ID: 2205
mRNA Refseq: NM_002001
Protein Refseq: NP_001992
MIM: 147140
UniProt ID: P12319
Chromosome Location: 1q23
Pathway: Asthma, organism-specific biosystem; Asthma, conserved biosystem; Fc epsilon RI signaling pathway, organism-specific biosystem; Fc epsilon RI signaling pathway, conserved biosystem; Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem;
Function: IgE binding; receptor activity;

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