Active Human Transferrin Reference Standard

• Cat.No.: TF-24H

Specification

• Description: Human transferrin is a single-chain glycoprotein. It has two potential N-linked glycosylation sites and one potential O-linked glycosylation site. Transferrin binds two Fe3+ ions, with high affinity (Kd ≈ 10?20 M), together with two synergistically bound CO32- ions. The protein is mainly synthesized in the liver and secreted into the plasma. Lower amounts are also produced in other organs, such as the testis and brain. Transferrin is also capable of acting as a cytokine and has additional functions that may not be related to its iron-carrying capacity. Other roles for transferrin include acting as a neurotrophic factor in myotubule formation and as an angiogenic factor in promoting the migration and invasion of endothelial cells.
• Species: Human
• Form: Liquid
• Bio-activity: The level of Transferrin in the serum was quantified using ELISA.
• Usage: For research use only, not for diagnostic or therapeutic use.
• Quality Control Test: Generated from a human serum pool. This lot has been tested by standard laboratory procedures and found to be negative for HIV 1, HIV 2, Hepatitis B and Hepatitis C.
• Storage: Stored at -20 °C, 4 °C for less than seven days, frozen for greater than seven days.
• Concentration: 3.4 mg/ml
• Preservative: 0.1% sodium azide

Gene Information

• Gene Name: TF transferrin [ Homo sapiens ]
• Official Symbol: TF
• Synonyms: TF; transferrin; serotransferrin; PRO1557; PRO2086; siderophilin; beta-1 metal-binding globulin; TFQTL1; DKFZp781D0156
• Gene ID: 7018
• mRNA Refseq: NM_001063
• Protein Refseq: NP_001054
• MIM: 190000
• UniProt ID: P02787
• Chromosome Location: 3q21
• Pathway: EPHB forward signaling, organism-specific biosystem; HIF-1-alpha transcription factor network, organism-specific biosystem; Hemostasis, organism-specific biosystem; Iron uptake and transport, organism-specific biosystem; Mineral absorption, organism-specific biosystem; Mineral absorption, conserved biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem
• Function: ferric iron binding; metal ion binding; protein binding; ubiquitin protein ligase binding