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Recombinant Human Aryl hydrocarbon receptor LBD/Hsp90 complex, GST-tagged

Cat.No.: AHR-109H
Product Overview: Recombinant Human GST-tagged Aryl hydrocarbon receptor ligand-binding domain (AhR-LBD) consists of a 218 a.a. GST tag, a 16 a.a. flexible linker and a 207 a.a. Aryl hydrocarbon receptor ligand binding domain, Acc# NP_001612.1, amino acids 231-437. Human Aryl hydrocarbon receptor ligand-binding domain in complex with human Hsp90 was produced in insect cells co-infected with two recombinant baculoviruses. GST tagged AhR-LBD and Hsp90 are the major components of the complex.
Description: In the cytoplasm Aryl hydrocarbon receptor is found in complex with Hsp90. Complex of Aryl hydrocarbon receptor with Hsp90 is essential for ligand-dependent activation of the receptor.
Source: Sf9 insect cells
Species: Human
Tag: GST
Form: 20 mM Na-P pH 8.0, 40 mM KCl, 20 mM Na2MoO4, 7 mM reduced glutathione, 15% glycerol.
Purity: >80%
Applications: Development of Ligand binding and coactivator peptide recruitment assays.
Storage: Immediately store at -80℃. Avoid freeze-thaw cycles.While working, please keep sample on ice.
Gene Name: AHR aryl hydrocarbon receptor [ Homo sapiens ]
Official Symbol: AHR
Synonyms: AHR; aryl hydrocarbon receptor; bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76;
Gene ID: 196
mRNA Refseq: NM_001621
Protein Refseq: NP_001612
MIM: 600253
UniProt ID: P35869
Chromosome Location: 7p15
Pathway: Adipogenesis, organism-specific biosystem;
Function: DNA binding; DNA binding; Hsp90 protein binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; protein binding; protein dimerization activity; protein heterodimerization activity; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific distal enhancer binding RNA polymerase II transcription factor activity; signal transducer activity; transcription factor binding; transcription regulatory region DNA binding;

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