Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Chicken ACTC1

Cat.No. : ACTC1-3520C
Product Overview : Recombinant Chicken ACTC1 full length or partial length protein was expressed.
  • Specification
  • Gene Information
  • Related Products
Source : Mammalian Cells
Species : Chicken
Tag : His
Form : Liquid or lyophilized powder
Endotoxin : < 1.0 eu per μg of the protein as determined by the LAL method.
Purity : >80%
Notes : This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Storage : Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC.
Storage Buffer : PBS buffer
Gene Name : ACTC1 actin, alpha, cardiac muscle 1 [ Gallus gallus (chicken) ]
Official Symbol : ACTC1
Gene ID : 423298
Protein Refseq : NP_001072949
UniProt ID : P68034

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (20)

Ask a question
What is the association between ACTC1 mutations and cardiac diseases? 10/18/2022

ACTC1 mutations, such as the G247D mutation, have been linked to atrial-septal defect followed by late-onset dilated cardiomyopathy (DCM).

How does knockdown of ACTC1 affect U87MG cell migration? 10/08/2022

Knockdown of ACTC1 inhibits U87MG cell migration.

What genetic factors regulate Actc1 expression in heart and skeletal muscle? 11/03/2021

Significant expression quantitative trait loci (eQTL) associated with Actc1 expression have been identified in both heart and soleus (a skeletal muscle)

What are the specific cardiac conditions associated with ACTC1 mutations? 08/14/2021

ACTC1 mutations have been implicated in atrial septal defect, dilated cardiomyopathy, hypertrophic cardiomyopathy, and left ventricular noncompaction.

What is the role of ACTC1 in muscle function? 07/15/2021

ACTC1 encodes a highly conserved actin protein that binds to myosin in both cardiac and skeletal muscle, suggesting shared functions between the two muscle types.

What is the relationship between ACTA1 and ACTC1 in muscle diseases? 02/13/2021

Mutations in the ACTA1 gene, which encodes skeletal muscle α-actin, can cause lethal muscle diseases. However, transgenic over-expression of cardiac α-actin (ACTC1) has been shown to rescue the disease phenotype in ACTA1 mouse models.

How does the discovery of mutations in ACTC1 contribute to our understanding of genetic disorders? 12/05/2020

The discovery of mutations in ACTC1 expands our knowledge of genetic disorders and identifies a new condition associated with ACTC1 mutations, highlighting the importance of this gene in muscle-related conditions.

What are some cardiac conditions associated with mutations in ACTC1? 07/18/2020

Mutations in ACTC1 have been linked to atrial septal defect, dilated cardiomyopathy, hypertrophic cardiomyopathy, and left ventricular noncompaction.

What is the functional impact of the G247D ACTC1 mutation? 04/20/2020

The G247D ACTC1 mutation negatively regulates serum response (SRF)-signaling, which contributes to the development of late-onset DCM.

How does transgenic over-expression of ACTC1 impact the disease phenotype in ACTA1 mouse models? 12/04/2019

Transgenic over-expression of ACTC1 rescues the disease phenotype observed in ACTA1 mouse models, which are affected by lethal muscle diseases.

What marks of regulatory potential were examined in relation to Actc1 expression? 10/18/2019

Studies have examined methylation, histone modification, and chromatin accessibility as marks of regulatory potential, with methylation around the Actc1 transcriptional start site showing a strain-dependent correlation with Actc1 expression in skeletal muscle.

What does the shared function of ACTC1 in cardiac and skeletal muscle suggest? 05/23/2018

The shared functions of ACTC1 in both cardiac and skeletal muscle indicate overlapping roles and potential implications for muscle function and disease processes.

How does Actc1 expression vary in skeletal muscle among different strains? 05/18/2018

Actc1 expression can vary up to 24-fold in skeletal muscle among different strains, as observed in the strains from The Collaborative Cross (CC) genetic resource.

What is the significance of ACTC1 in clinical cases of GBM migration? 05/13/2018

ACTC1 has been identified as a potential marker to detect GBM migration in clinical cases.

How does the conservation of ACTC1 actin protein relate to its role in muscle function? 10/25/2016

The highly conserved nature of the ACTC1 actin protein suggests its fundamental importance in muscle function across species.

What implications does the shared function of ACTC1 in cardiac and skeletal muscle have for medical research? 09/28/2016

The shared functions of ACTC1 in cardiac and skeletal muscle indicate potential overlapping mechanisms in muscle-related diseases and may guide future research and therapeutic approaches targeting ACTC1-related conditions.

What is the predominant isoform of α-actin in the heart? 09/10/2016

ACTC1 is the predominant striated α-actin isoform in the heart.

How is methylation around the Actc1 transcriptional start site related to Actc1 expression in skeletal muscle? 07/07/2016

Methylation around the Actc1 transcriptional start site in early adult skeletal muscle negatively correlates with Actc1 expression in a strain-dependent manner, indicating a potential regulatory role.

What role does reduced ACTC1 expression play in the onset of CHD? 05/04/2016

Reduced ACTC1 expression may contribute to the onset of congenital heart disease (CHD) through the induction of cardiomyocyte apoptosis.

How does Actc1 expression vary in skeletal muscle? 03/26/2016

Actc1 expression can vary up to 24-fold in skeletal muscle, as observed in strains from The Collaborative Cross (CC) genetic resource.

Customer Reviews (5)

Write a review
Reviews
10/13/2021

    The protein product delivers exceptional results, surpassing our expectations in terms of its effectiveness.

    01/29/2021

      The protein product demonstrates exceptional purity, free from any interfering impurities.

      04/12/2020

        The protein product maintains remarkable consistency across multiple batches, ensuring reproducibility in our experiments.

        07/31/2016

          The customer support provided by the company is exceptional, promptly addressing any inquiries or concerns.

          02/22/2016

            The protein product was delivered in a timely manner, and the packaging was secure, ensuring product integrity.

            Ask a Question for All ACTC1 Products

            Required fields are marked with *

            My Review for All ACTC1 Products

            Required fields are marked with *

            0

            Inquiry Basket

            cartIcon
            logo

            FOLLOW US

            Terms and Conditions        Privacy Policy

            Copyright © 2024 Creative BioMart. All Rights Reserved.

            Contact Us

            • /

            Stay Updated on the Latest Bioscience Trends