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Recombinant Human CTTN, GST-tagged

Cat.No. : CTTN-27H
Product Overview : Recombinant Human CTTN ( 1 a.a. - 513 a.a.), fused with GST-tag at N-terminal, was expressed in Wheat Germ.
  • Specification
  • Gene Information
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Description : This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene.
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 83.9 kDa
AA Sequence : MWKASAGHAVSIAQDDAGADDWETD PDFVNDVSEKEQRWGAKTVQGSGHQ EHINIHKLRENVFQEHQTLKEKELE TGPKASHGYGGKFGVEQDRMDKSAV GHEYQSKLSKHCSQVDSVRGFGGKF GVQMDRVDQSAVGFEYQGKTEKHAS QKDYSSGFGGKYGVQADRVDKSAVG FDYQGKTEKHESQRDYSKGFGGKYG IDKDKVDKSAVGFEYQGKTEKHESQ KDYVKGFGGKFGVQTDRQDKCALGW DHQEKLQLHESQKDYSKGFGGKYGV QKDRMDKNASTFEDVTQVSSAYQKT VPVEAVTSKTSNIRANFENLAKEKE QEDRRKAEAERAQRMAKERQEQEEA RRKLEEQARAKTQTPPVSPAPQPTE ERLPSSPVYEDAASFKAELSYRGPV SGTEPEPVYSMEAADYREASSQQGL AYATEAVYESAEAPGHYPAEDSTYD EYENDLGITAVALYDYQAAGDDEIS FDPDDIITNIEMIDDGWWRGVCKGR YGLFPANYVELRQ
Applications : ELISA; WB-Re; AP; Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CTTN cortactin [ Homo sapiens (human) ]
Official Symbol : CTTN
Synonyms : CTTN; cortactin; EMS1, ems1 sequence (mammary tumor and squamous cell carcinoma associated (p80/85 src substrate); src substrate cortactin
Gene ID : 2017
mRNA Refseq : NM_138565
Protein Refseq : NP_612632
MIM : 164765
UniProt ID : Q14247
Chromosome Location : 11q13
Pathway : Bacterial invasion of epithelial cells; FGF signaling pathway; Pathogenic Escherichia coli infection
Function : protein binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any molecular pathways that interact with CTTN protein in cancer cells? 03/20/2022

Yes, CTTN protein interacts with various signaling pathways involved in cancer progression, including those regulating cell migration and invasion.

How is CTTN protein expression assessed in clinical settings? 01/12/2022

CTTN protein expression can be evaluated using immunohistochemistry on tumor tissue samples obtained from patients.

Are there any non-cancer clinical applications of CTTN protein? 08/01/2020

Yes, CTTN protein has been implicated in neurological disorders such as Alzheimer's disease, and its role in these conditions is also being investigated.

Is CTTN protein involved in other cellular functions besides cancer progression? 03/21/2019

Yes, CTTN protein is involved in various cellular processes such as cell adhesion, migration, and cytoskeletal dynamics.

How is CTTN protein expression regulated in cancer cells? 01/17/2016

CTTN protein expression can be regulated by various factors, including oncogenes, tumor suppressor genes, and signaling pathways involved in cancer development.

Customer Reviews (3)

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Reviews
01/19/2021

    Its high quality, coupled with the manufacturer's exceptional technical support, make it a reliable and effective choice for addressing my scientific inquiries.

    05/17/2017

      This has greatly facilitated my experimental workflow, ensuring a readily available and dependable protein source whenever I need it.

      12/15/2016

        I confidently recommend the CTTN protein to any researcher seeking a superior protein that not only fulfills their experimental needs but is also backed by unparalleled support from the manufacturer.

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