Recombinant Human ALPL therapeutic protein
Cat.No. : | ALPL-P04H |
Product Overview : | Recombinant Human TNSALP therapeutic protein is a fusion protein incorporating the catalytic domain of human tissue non-specific alkaline phosphatase (TNSALP; ALPL) and a bone-targeting peptide. It is designed to address the underlying cause of HPP by normalizing the genetically defective metabolic process, and preventing or reversing the severe and potentially life-threatening complications of life-long dysregulated mineral metabolism. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. |
Species : | Human |
Endotoxin : | < 0.1 EU per μg of the protein |
Purity : | >95% |
Gene Name : | ALPL alkaline phosphatase, liver/bone/kidney [ Homo sapiens ] |
Official Symbol : | ALPL |
Synonyms : | ALPL; alkaline phosphatase, liver/bone/kidney; HOPS; alkaline phosphatase, tissue-nonspecific isozyme; TNSALP; glycerophosphatase; tissue-nonspecific ALP; alkaline phosphomonoesterase; liver/bone/kidney-type alkaline phosphatase; alkaline phosphatase liver/bone/kidney isozyme; TNAP; APTNAP; AP-TNAP; FLJ40094; FLJ93059; MGC161443; MGC167935; |
Gene ID : | 249 |
mRNA Refseq : | NM_000478 |
Protein Refseq : | NP_000469 |
MIM : | 171760 |
UniProt ID : | P05186 |
Chromosome Location : | 1p36.12 |
Pathway : | Endochondral Ossification, organism-specific biosystem; Folate biosynthesis, organism-specific biosystem; Folate biosynthesis, conserved biosystem; Metabolic pathways, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem; |
Function : | alkaline phosphatase activity; hydrolase activity; metal ion binding; |
Products Types
◆ Recombinant Protein | ||
Alpl-564M | Recombinant Mouse Alpl Protein, MYC/DDK-tagged | +Inquiry |
ALPL-1299M | Recombinant Mouse ALPL Protein (20-503 aa), His-tagged | +Inquiry |
ALPL-2458H | Recombinant Human ALPL Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPL-138R | Recombinant Rhesus Macaque ALPL Protein, His (Fc)-Avi-tagged | +Inquiry |
Alpl-487M | Recombinant Mouse Alpl Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Native Protein | ||
ALPL-25H | Active Native Human ALPL Protein | +Inquiry |
ALPL-66C | Active Native Calf Alkaline Phosphatase | +Inquiry |
ALPL-5324H | Active Native Human Alkaline Phosphatase | +Inquiry |
◆ Lysates | ||
ALPL-3092HCL | Recombinant Human ALPL cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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