"TNFRSF13B" Related Products

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Recombinant Human TACI, Fc-tagged (Atacicept)

Cat.No.: TNFRSF13B-P05H
Product Overview: The protein combines the binding site for two cytokines that regulate maturation, function, and survival of B cells, B-lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), with the constant region of immunoglobin. It blocks activation of B cells by the tumor necrosis factor receptor superfamily member 13B (more commonly known as TACI), a transmembrane receptor protein found predominantly on the surface of B cells. Like the monoclonal antibody belimumab, atacicept blocks the binding of BLyS, but it also blocks APRIL. Binding of these TACI ligands induces proliferation, activation, and longevity of B cells and thus their production of autoantibodies. The protein is thought to selectively impair mature B cells and plasma cells with less impact on progenitor cells and memory B cells.
Species: Human
CAS number: 845264-92-8
Endotoxin: < 0.1 eu per μg of the
Purity: >95%
Gene Name: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B [ Homo sapiens ]
Official Symbol: TNFRSF13B
Synonyms: TNFRSF13B; tumor necrosis factor receptor superfamily, member 13B; tumor necrosis factor receptor superfamily member 13B; CD267; TACI; tumor necrosis factor receptor 13B; transmembrane activator and CAML interactor; CVID; CVID2; TNFRSF14B; FLJ39942; MGC39952; MGC133214;
Gene ID: 23495
mRNA Refseq: NM_012452
Protein Refseq: NP_036584
MIM: 604907
UniProt ID: O14836
Chromosome Location: 17p11.2
Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Intestinal immune network for IgA production, organism-specific biosystem; Intestinal immune network for IgA production, conserved biosystem; Primary immunodeficiency, organism-specific biosystem; Primary immunodeficiency, conserved biosystem; Syndecan-2-mediated signaling events, organism-specific biosystem;
Function: protein binding; receptor activity;

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